May 22, 2025 | Biotech, Blog, Cell-Free
High-throughput screening (HTS) methods study the interactions between a great number of chemical compounds or biomolecules and a specific target, in a robust, highly reproducible and time-efficient format. This screening technology was motivated by the increased...
May 15, 2025 | Blog, Cell-Free, Proteins, Uncategorized
Cell-free production of adeno-associated virus protein particles – Expanded horizons for gene therapy and vaccine development Virus-like proteins (VLPs) are non-infectious polymeric nanoparticles formed from virus-coat proteins but deprived of genetic material. These...
Oct 3, 2023 | Blog, Cell-Free
Les particules pseudovirales (VLP) sont des nanostructures constituées de protéines virales assemblées, dépourvues de matériel génétique viral et donc non infectieuses. Leur intérêt réside dans la possibilité de les utiliser pour transporter et délivrer des...
Jul 24, 2023 | Cell-Free, Proteins
Les amyloïdes sont des agrégats de protéines présentant une structure fibrillaire non ramifiée typique, qui sont impliqués dans plusieurs maladies de mauvais repliement des protéines, associées à des maladies neurodégénératives telles que les maladies...
Mar 25, 2022 | Cell-Free, Proteins, Proteoliposomes
Synthelis’ cell-free liposome-based expression system was applied in the development of an OprF vaccine against Pseudomonas aeruginosa. The complete OprF outer membrane protein of P. aeruginosa was used as the immunogen and was expressed in its native form in...
Mar 20, 2022 | Biotech, Cell-Free
Cell-free protein expression offers a rapid, reliable technique for synthesis of proteins. Successfully synthesizing large quantities of high-quality product requires finding the optimal protein expression conditions, such as the type of cellular extract used. Lysate...
Mar 20, 2022 | Cell-Free, Proteins
Isotope labelling has been used for over 40 years to facilitate the study of protein structure using nuclear magnetic resonance (NMR) spectroscopy. During that time, traditional expression systems such as in vivo protein synthesis were the preferred options for...