over us,
we watch
over them.

Cell-Free Systems Applications


Society and technology are changing. From bioengineering to artificial intelligence, from human to exact sciences, from industry to a newfound respect for the living – we are witnessing an era of huge importance – one where a myriad of sciences converge, an era of endless technological and socio-economic opportunity. As a leading French player in cell-free systems, Synthelis is proud to be part of this industrial revolution and the shift from chemistry to biology. Our proprietary cell-free expression technology opens up new socio-economic horizons for the development and production of innovative health products. By designing biomolecules for pharmaceutical, biomedical and biotechnological research organisations and academic laboratories, we help contribute to answering the societal and ethical challenges of our time.

« Let’s work together to design the bioactive proteins of the future »

Bruno Tillier – COO Synthelis

Bruno Tiller - Président Directeur Général et Cofondateur - Synthelis

Our customers talk about it

Enterome logo Témoignage

"We worked with the Synthelis team for two years on a large-scale project for cell-free protein synthesis. In addition to their perfect knowledge of protein synthesis in different conditions, quantification & validation, the team is fully dedicated to our project, working with flexibility and perfect communication."

Laurent CHENE


Sanofi logo témoignage

"Synthelis team was very efficient to provide us with a solution to our persistent inclusion body issue. We believe that the cell-free could be a promising alternative expression system to overcome some bottlenecks."




"Synthelis' team was efficient and professional in providing us with a solution for the rapid development of a biological reagent for coagulation diagnosis. Synthelis' cell-free technology is particularly effective in producing large quantities of complex membrane proteins. What makes the difference in working with Synthelis is their expertise in their technology and their professionalism. I can recommend working with Synthelis because their team and their technology allow to accelerate project development."

Vincent POHER



"At Twist Biopharma, we were looking for a supplier to produce membrane proteins as GPCRs to perform our phage display campaigns. Synthelis took our specifications for this project into consideration, adapted its cell-free expression technology, and supplied us with a challenging receptor in a very short timeline. The quality of the supplied target enabled us to successfully select antagonist and agonist VHH binders confirmed in our bioassays. We are fully satisfied with our collaboration with Synthelis."

Aaron SATO

Chief Scientific Officer TWIST BIOPHARMA

the experts in Cell-Free technology.

Cytotoxic proteins, ion channels, GPCRs, antigens, transporters, enzymes, etc.


A wide-ranging base of international customers including 9 big pharma clients


Difficult proteins successfully produced


Proprietary cell-free technology at optimised cost of goods


Vast network of academic and industrial partners: biomedicines, vaccines, IVD, structural biology etc.


Auditable quality management system
ISO 9001

Fields of application

Our proprietary technology is recognized as a European benchmark. It allows us to provide innovative and customized solutions including: membrane proteins, enzymes, antigens, GPCRs, etc. Because proteins are biological molecules essential to the discovery and development of future vaccines, biomedicines and diagnostic reagents, they are the keys needed to unlock the future product developments. However, their potential is not just limited to healthcare and medicine. Applied biotechnology, environmental biotechnology, food and energy are all dependent on proteins , and so can all benefit from the Synthelis cell-free technology.

The futures
of innovation
are bio…

10 myths
about Cell-Free

that you probably
always believed
We look
forward to
your questions
a protein
to express
its potential

Cell-Free Systems Applications

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