{"id":5225,"date":"2025-03-20T19:40:40","date_gmt":"2025-03-20T18:40:40","guid":{"rendered":"https:\/\/synthelis.com\/2025-pro-substrat-bioluminescent-hikarazine-z-108\/"},"modified":"2026-03-20T11:47:58","modified_gmt":"2026-03-20T10:47:58","slug":"pro-substrat-bioluminescent-hikarazine-z-108","status":"publish","type":"page","link":"https:\/\/synthelis.com\/en\/pro-substrat-bioluminescent-hikarazine-z-108\/","title":{"rendered":"Bioluminescence Pro-substrate Hikarazine\u2122 Z108"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px||0px||true|false” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” _builder_version=”4.27.4″ _module_preset=”default” width=”100%” max_width=”100%” min_height=”50vh” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.27.4″ _module_preset=”default” background_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2025\/03\/Synthelis-Technologie-Bioluminescence-HikarazineZ108.webp” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” background_layout=”dark” min_height=”33vh” custom_margin=”0px||||false|false” global_colors_info=”{}”][\/et_pb_text][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” use_background_color_gradient=”on” background_color_gradient_direction=”45deg” background_color_gradient_stops=”#29102e 6%|#4d1749 65%” background_color_gradient_start=”#29102e” background_color_gradient_start_position=”6%” background_color_gradient_end=”#4d1749″ background_color_gradient_end_position=”65%” custom_padding=”78px|65px|78px|65px|true|true” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”Rufina||||||||” text_text_color=”#FFFFFF” text_font_size=”4em” text_line_height=”1em” header_font=”Rufina||||||||” header_text_color=”#FFFFFF” header_font_size=”45px” header_font_size_tablet=”55px” header_font_size_phone=”30px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

Bioluminescence<\/h1>\n

Pro-substrate<\/h1>\n

Hikarazine\u2122
Z108<\/h1>\n

[\/et_pb_text][et_pb_divider show_divider=”off” _builder_version=”4.16″ _module_preset=”default” width=”100%” height=”50px” global_colors_info=”{}”][\/et_pb_divider][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” background_layout=”dark” custom_margin=”0px||||false|false” global_colors_info=”{}”][\/et_pb_text][et_pb_divider show_divider=”off” _builder_version=”4.16″ _module_preset=”default” width=”100%” height=”50px” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”caracterisation” _builder_version=”4.27.4″ _module_preset=”default” background_color=”#FFFFFF” custom_margin=”0px||||false|false” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||||true|false” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][dnxte_coverflowslider_parent dnxte_coverflow_autoplay_delay=”3200″ dnxte_coverflow_loop=”on” dnxte_coverflow_speed=”850″ dnxte_coverflow_breakpoint_desktop=”1″ dnxte_coverflow_arrow_color=”#29102E” dnxte_coverflow_dots_color=”#EDE8EC” dnxte_coverflow_dots_active_color=”#4D1749″ _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][dnxte_coverflowslider_child admin_label_text=”Hikarazine Boite Z-108″ coverflowslider_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2026\/03\/Hikarazine-Boite-108.webp” coverflowslider_alt=”Hikarazine Boite Z-108″ _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][\/dnxte_coverflowslider_child][dnxte_coverflowslider_child admin_label_text=”HIKARAZINE Z108 OPEN BOX” coverflowslider_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2026\/03\/HIKARAZINE-Z108-OPEN-BOX-SYNTHELIS-BIOTECH-BD.webp” coverflowslider_alt=”HIKARAZINE Z108 OPEN BOX SYNTHELIS BIOTECH BD” _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][\/dnxte_coverflowslider_child][dnxte_coverflowslider_child admin_label_text=”HIKARAZINE Z108 BAG” coverflowslider_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2026\/03\/HIKARAZINE-Z108-BAG-SYNTHELIS-BIOTECH-BD.webp” coverflowslider_alt=”HIKARAZINE Z108 BAG SYNTHELIS BIOTECH BD” _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][\/dnxte_coverflowslider_child][\/dnxte_coverflowslider_parent][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” custom_css_main_element=”margin: auto;” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#4D1749″ text_font_size=”1.9em” text_line_height=”1.3em” text_font_size_tablet=”1.7em” text_font_size_phone=”1.6em” text_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

Hikarazine\u2122 Z108 is the brightest substrate in the Hikarazine\u2122 range.<\/strong> With a half-life of 1 hour, Hikarazine\u2122 Z108 is ideal for enhancing sensitivity and for applications where the number of emitted photons is critical.
The use of Hikarazine\u2122 Z108 is reserved for research in biology (RUO) by professionals.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_5,1_5,1_5,1_5,1_5″ use_custom_gutter=”on” gutter_width=”2″ make_equal=”on” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||||true|false” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”1_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif|700|||||||” text_text_color=”#72486E” background_color=”#EDE8EC” text_orientation=”center” custom_margin=”||15px||false|false” custom_padding=”10px||10px||true|false” global_colors_info=”{}”]<\/p>\n

SYN90007-1-01
1 x 1 mg<\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif|700|||||||” text_text_color=”#4D1749″ background_color=”#FFFFFF” text_orientation=”center” custom_margin=”0px||||false|false” custom_padding=”||||true|false” global_colors_info=”{}”]<\/p>\n

400 \u20ac<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif|700|||||||” text_text_color=”#72486E” background_color=”#EDE8EC” text_orientation=”center” custom_margin=”||15px||false|false” custom_padding=”10px||10px||true|false” global_colors_info=”{}”]<\/p>\n

SYN90007-5-01
5 x 1 mg<\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif|700|||||||” text_text_color=”#4D1749″ background_color=”#FFFFFF” text_orientation=”center” custom_margin=”0px||||false|false” custom_padding=”||||true|false” global_colors_info=”{}”]<\/p>\n

1 600 \u20ac<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif|700|||||||” text_text_color=”#72486E” background_color=”#EDE8EC” text_orientation=”center” custom_margin=”||15px||false|false” custom_padding=”10px||10px||true|false” global_colors_info=”{}”]<\/p>\n

SYN90007-10-01
10 x 1 mg<\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif|700|||||||” text_text_color=”#4D1749″ background_color=”#FFFFFF” text_orientation=”center” custom_margin=”0px||||false|false” custom_padding=”||||true|false” global_colors_info=”{}”]<\/p>\n

3 000 \u20ac<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif|700|||||||” text_text_color=”#72486E” background_color=”#EDE8EC” text_orientation=”center” custom_margin=”||15px||false|false” custom_padding=”10px||10px||true|false” global_colors_info=”{}”]<\/p>\n

50, 100, 250 mg<\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif|700|||||||” text_text_color=”#4D1749″ background_color=”#FFFFFF” text_orientation=”center” custom_margin=”0px||||false|false” custom_padding=”||||true|false” global_colors_info=”{}”]<\/p>\n

On request<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif|700|||||||” text_text_color=”#FFFFFF” background_color=”#4D1749″ text_orientation=”center” custom_margin=”||15px||false|false” custom_padding=”10px||10px||true|false” link_option_url=”https:\/\/hello.synthelis.com\/en\/order-hikarazine-sample” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

Receive a sample<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”caracterisation” _builder_version=”4.27.4″ _module_preset=”default” background_color=”#EDE8EC” custom_margin=”0px||||false|false” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” custom_margin=”||||true|false” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][dnxte_advanced_tab hover_effect=”dnxt-hover-fadeIn ” tab_hover_effect=”none” tab_wrapper_margin=”||||false|false” body_wrapper_margin=”|0px||0px|false|false” body_wrapper_padding=”30px|0px||0px|false|false” tab_container_bg_color=”RGBA(255,255,255,0)” tab_single_bg_color=”RGBA(255,255,255,0)” tab_active_bg_color=”RGBA(255,255,255,0)” content_container_bg_color=”RGBA(255,255,255,0)” _builder_version=”4.27.6″ _module_preset=”default” tab_title_font=”PT Serif|700|||||||” tab_title_text_color=”#D2C6D2″ tab_title_font_size=”25px” tab_active_title_text_color=”#4D1749″ width=”100%” max_width=”100%” custom_margin=”0px|0px||0px|false|false” custom_padding=”|0px||0px|false|false” hover_enabled=”0″ border_width_bottom_tab_active=”3px” border_color_bottom_tab_active=”#4D1749″ global_colors_info=”{}” sticky_enabled=”0″][dnxte_advanced_tab_item admin_label_text=”Descriptif” tab_title=”Description” body_description=”<\/p>\n

Hikarazine\u2122 represents a patented class of bioluminescent pro-substrates (commonly known as pro-luciferins),<\/strong> specially designed for use with luciferase enzymes derived from Oplophorus gracilirostris.
The Hikarazine pro-substrates are provided in a dry form of 1 mg and are stable for 2 years at room temperature. Activation of the pro-substrates into substrates is straightforward, resulting in a stock solution that is stable at 4\u00b0C for 6 months. Depending on the type of bioluminescent assay and protocol used, 1 mg of Hikarazine\u2122 allows for the following<\/strong> (assumption: 96-well plate):
\u2022 2,500 to 3,000 immunological or enzymatic tests
\u2022 750 to 1,500 live cell assays
\u2022 Up to 20 in vivo tests on small animals<\/strong><\/p>\n

Hikarazine\u2122 Z108 is the brightest substrate in the Hikarazine\u2122 range. With a half-life of 1 hour, Hikarazine\u2122 Z108 is ideal for increasing sensitivity and for applications where the number of emitted photons is crucial.<\/p>\n

” tab_item_margin=”||||false|false” _builder_version=”4.27.4″ _module_preset=”default” description_font=”PT Serif||||||||” description_font_size=”1.4em” description_line_height=”1.5em” width=”1080px” max_width=”100%” global_colors_info=”{}”][\/dnxte_advanced_tab_item][dnxte_advanced_tab_item admin_label_text=”Avantages” tab_title=”Advantages” body_description=”<\/p>\n

Advantages of Hikarazine\u2122 Z108:
. Optimized brightness<\/strong> (2 to 15 times brighter than standard luciferine substrate depending on the enzyme and buffer used)
. Increased solubility<\/strong> for enhanced biological availability
. Pro-substrate stable for 2 years<\/strong> at room temperature
. Reduced transportation cost<\/strong>
. Activated substrate stock solution<\/strong> stable for 6 months at 4\u00b0C
. Competitive pricing<\/strong><\/p>\n

” _builder_version=”4.27.4″ _module_preset=”default” description_font=”PT Serif||||||||” description_font_size=”1.4em” description_line_height=”1.5em” global_colors_info=”{}”][\/dnxte_advanced_tab_item][dnxte_advanced_tab_item admin_label_text=”IFU” tab_title=”IFU” body_description=”<\/p>\n

%22Thumbnail<\/a><\/p>\n

” button_text=”IFU – Download” button_link=”https:\/\/synthelis.com\/wp-content\/uploads\/2025\/03\/2025-03-19_IFU_Hikarazine_EN-V1R01.pdf” button_target=”_blank” _builder_version=”4.27.4″ _module_preset=”default” description_font=”PT Serif||||||||” description_font_size=”1.4em” description_line_height=”1.5em” global_colors_info=”{}”][\/dnxte_advanced_tab_item][dnxte_advanced_tab_item admin_label_text=”MSDS” tab_title=”MSDS” body_description=”<\/p>\n

%22Vignette<\/a><\/p>\n

” button_text=”MSDS – Download” button_link=”http:\/\/synthelis.com\/wp-content\/uploads\/2026\/03\/MSDS-Hikarazine-Z108-1.pdf” button_target=”_blank” _builder_version=”4.27.6″ _module_preset=”default” description_font=”PT Serif||||||||” description_font_size=”1.4em” description_line_height=”1.5em” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][\/dnxte_advanced_tab_item][dnxte_advanced_tab_item admin_label_text=”CoA” tab_title=”CoA” body_description=”<\/p>\n

%22Thumbnail<\/p>\n

” button_text=”Certificate of Analysis – Sent with the order” _builder_version=”4.27.4″ _module_preset=”default” description_font=”PT Serif||||||||” description_font_size=”1.4em” description_line_height=”1.5em” global_colors_info=”{}”][\/dnxte_advanced_tab_item][\/dnxte_advanced_tab][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” _builder_version=”4.27.4″ _module_preset=”default” background_color=”#FFFFFF” disabled=”on” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ header_5_font=”PT Serif|700|||||||” header_5_font_size=”30px” border_color_bottom=”#EEEFF3″ global_colors_info=”{}”]<\/p>\n

Application domains<\/h5>\n

[\/et_pb_text][et_pb_divider color=”#D2C6D2″ divider_position=”center” _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||0px||true|false” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][dnxte_blurb blurb_pre_switch=”on” blurb_pre_heading=”\u00c0 compl\u00e9ter” pre_heading_tag=”p” blurb_heading=”Biomedicines” heading_tag=”h6″ dnxt_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2022\/03\/Synthelis-Applications-Biomedicaments.jpg” dnxt_content_max_width=”90%” dnxt_pre_margin=”-30px||10px||false|false” dnxt_pre_padding=”20px|25px||25px|false|true” dnxt_header_padding=”|25px|30px|25px|false|true” dnxt_post_margin=”||||false|false” dnxt_post_padding=”||||false|false” dnxt_body_margin=”|||51px|false|false” dnxt_content_margin=”||||false|false” heading_bg_show_hide=”on” heading_bg=”#FFFFFF” btn_icon=”5||divi||400″ btn_icon_color=”#FFFFFF” blurb_hover_switch=”on” dnxt_hover_effect=”dnxt-hover-wobble-to-bottom-right” _builder_version=”4.27.4″ _module_preset=”default” dnxt_pre_header_font=”|700|||||||” dnxt_heading_text_color=”#4D1749″ dnxt_heading_font_size=”30px” dnxt_btn_text_font=”PT Serif||||||||” dnxt_btn_text_text_color=”#FFFFFF” background_color=”RGBA(255,255,255,0)” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7211207\/pdf\/40259_2020_Article_417.pdf” link_option_url_new_window=”on” border_width_all_dnxt_button_borders=”0px” box_shadow_style_dnxt_description_boxshadow=”preset3″ box_shadow_style_dnxt_button_boxshadow=”preset3″ global_colors_info=”{}”][\/dnxte_blurb][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][dnxte_blurb blurb_pre_switch=”on” blurb_pre_heading=”\u00c0 completer” pre_heading_tag=”p” blurb_heading=”Synthetic biology” heading_tag=”h4″ dnxt_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2022\/03\/Synthelis-Applications-Biologie-Synthese.jpg” dnxt_content_max_width=”90%” dnxt_pre_margin=”-30px||10px||false|false” dnxt_pre_padding=”20px|25px||25px|false|true” dnxt_header_padding=”|25px|30px|25px|false|true” dnxt_post_margin=”||||false|false” dnxt_post_padding=”||||false|false” dnxt_body_margin=”|||51px|false|false” dnxt_content_margin=”||||false|false” heading_bg_show_hide=”on” heading_bg=”#FFFFFF” btn_icon=”5||divi||400″ btn_icon_color=”#FFFFFF” blurb_hover_switch=”on” dnxt_hover_effect=”dnxt-hover-wobble-to-bottom-right” _builder_version=”4.27.4″ _module_preset=”default” dnxt_pre_header_font=”|700|||||||” dnxt_heading_text_color=”#4D1749″ dnxt_heading_font_size=”30px” dnxt_btn_text_font=”PT Serif||||||||” dnxt_btn_text_text_color=”#FFFFFF” background_color=”RGBA(255,255,255,0)” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”http:\/\/synthelis.com\/wp-content\/uploads\/2022\/03\/CaseStudy-SanofiPasteur.pdf” link_option_url_new_window=”on” border_width_all_dnxt_button_borders=”0px” box_shadow_style_dnxt_description_boxshadow=”preset3″ box_shadow_style_dnxt_button_boxshadow=”preset3″ global_colors_info=”{}”][\/dnxte_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” _builder_version=”4.27.4″ _module_preset=”default” background_color=”#D2C6D2″ disabled=”on” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ header_3_font=”PT Serif|700|||||||” header_3_font_size=”30px” border_color_bottom=”#EEEFF3″ global_colors_info=”{}”]<\/p>\n

Application Notes<\/h3>\n

[\/et_pb_text][et_pb_divider color=”#D2C6D2″ divider_position=”center” _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||0px||true|false” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][dnxte_blurb blurb_pre_switch=”on” blurb_pre_heading=”pdf” pre_heading_tag=”p” blurb_heading=”Validation of a phage library-based panning strategy for the selection of specific anti-C5aR monoclonal antibodies” heading_tag=”h4″ dnxt_content_max_width=”90%” dnxt_pre_margin=”-30px||10px||false|false” dnxt_pre_padding=”20px|25px||25px|false|true” dnxt_header_padding=”|25px|30px|25px|false|true” dnxt_post_margin=”||||false|false” dnxt_post_padding=”||||false|false” dnxt_body_margin=”||||false|false” dnxt_content_margin=”||||false|false” 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header_text_color=”#4D1749″ header_3_font=”PT Serif|700|||||||” header_3_text_color=”#D2C6D2″ header_3_font_size=”30px” custom_margin=”||5px||false|false” custom_padding=”||||false|false” border_color_bottom=”#EEEFF3″ global_colors_info=”{}”]<\/p>\n

Titre de la vid\u00e9o tutorial<\/h3>\n

[\/et_pb_text][et_pb_divider color=”#72486E” divider_position=”center” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||20px||false|false” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||||true|false” custom_padding=”0px||||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_video src=”https:\/\/www.youtube.com\/watch?v=FkQuawiGWUw” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_video][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”faqbio” _builder_version=”4.27.4″ _module_preset=”default” background_color=”#EDE8EC” custom_padding=”||80px||false|false” global_colors_info=”{}”][et_pb_row use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ header_3_font=”PT Serif|700|||||||” header_3_font_size=”30px” custom_margin=”||5px||false|false” custom_padding=”||||false|false” border_color_bottom=”#EEEFF3″ global_colors_info=”{}”]<\/p>\n

FAQ<\/h3>\n

[\/et_pb_text][et_pb_divider color=”#D2C6D2″ divider_position=”center” _builder_version=”4.18.0″ _module_preset=”default” custom_margin=”||20px||false|false” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||||true|false” custom_padding=”0px||||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_accordion open_toggle_text_color=”#4D1749″ open_toggle_background_color=”RGBA(255,255,255,0)” closed_toggle_background_color=”RGBA(255,255,255,0)” toggle_icon=”||divi||400″ icon_color=”#4D1749″ use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.27.4″ _module_preset=”default” toggle_text_color=”#4D1749″ toggle_font=”PT Serif|700|||||||” toggle_font_size=”24px” body_font=”PT Serif||||||||” body_font_size=”1.4em” body_line_height=”1.4em” background_color=”RGBA(255,255,255,0)” border_width_all=”0px” border_style_all=”solid” border_width_bottom=”1px” border_color_bottom=”#4D1749″ global_colors_info=”{}” toggle_icon__hover_enabled=”off|desktop” toggle_icon__hover=”\ue044||divi||400″][et_pb_accordion_item title=”Which luciferases are compatible with Hikarazine\u2122?” open=”on” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

Hikarazine\u2122 has been specifically designed for use with luciferase enzymes derived from Oplophorus gracilirostris.<\/em><\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”Which Hikarazine\u2122 should I use?” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” open=”off”]<\/p>\n

The choice between Hikarazine\u2122 Z108 and Hikarazine\u2122 Z103 depends on your specific assay.
For applications where maximizing light output is crucial, such as bioluminescence microscopy and small animal imaging, Hikarazine\u2122 Z108 is generally the best choice.
For applications requiring longer monitoring times, Hikarazine\u2122 Z103 is recommended. Although it is slightly less bright, some users also report an improved signal-to-noise ratio under specific conditions when using Hikarazine\u2122 Z103.<\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”Which buffer should I use with Hikarazine\u2122?” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” open=”off”]<\/p>\n

The choice of buffer is crucial for optimal bioluminescence. PBS is recommended, but other buffers may be used depending on the assay. For instance, adding 0.01% Tween can help with complex matrices, though it may slightly increase background noise. Additionally, varying cation compositions can influence both brightness and bioluminescence half-life. If you need further guidance after testing in your specific assay, please contact our experts.<\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”What factors influence the light emission process and brightness?” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” open=”off”]<\/p>\n

The light emission and brightness of Hikarazine\u2122 are influenced by several factors:
. The amount of oxygen available at the luciferase site,
. The buffer composition, which can promote non-radiative relaxation of the substrate\u2019s excited state,
. Temperature, which can affect luciferase activity and the stability of the enzyme-substrate complex, thus altering light intensity,
. Ion concentration, particularly divalent cations, which can influence the efficiency of the bioluminescence reaction,
. The pH of the medium, as inappropriate pH can alter the luciferase enzyme’s activity,
. The presence of cofactors or inhibitors, as some compounds can enhance the reaction\u2019s efficiency, while others may reduce it.<\/p>\n

These factors must be optimized to ensure the best performance of the bioluminescent system using Hikarazine\u2122.<\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”What are the optimal storage conditions for maximum stability of the pro-substrate?” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” open=”off”]<\/p>\n

To ensure stability for up to two years, store the vials at room temperature, away from heat, light, and humidity.<\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”Why is the pro-substrate powder darkening?” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” open=”off”]<\/p>\n

A slight darkening of the surface of the solid may occur over time. However, this does not affect the bioluminescence signal, provided the pro-substrate is used under standard conditions recommended in the IFU.<\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”What are the optimal storage conditions for the stock solution?” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” open=”off”]<\/p>\n

The stock solution is acidic, which enhances its stability. When stored at 4\u00b0C, it remains stable for 6 months. For extended stability, it can be stored at -20\u00b0C, with ongoing tests to determine the exact duration.<\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”What is the peak emission of Hikarazine\u2122?” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” open=”off”]<\/p>\n

The peak bioluminescence emission of activated luciferins Hikarazine\u2122 Z103 and Z108 has been measured at 450 \u00b1 3 nm.<\/span><\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”What are the recommendations for small animal imaging?” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” open=”off”]<\/p>\n

Hikarazine\u2122 substrates contain fluor atoms, enhancing their solubility and bioavailability for small animal imaging. For optimal results, the final blood concentration should be around 13.6 \u00b5M, which corresponds to injecting 80 \u00b5L of Z103 or Z108 at 1.35 mM per mouse (assuming an average blood volume of 8 mL).<\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”Is Hikarazine\u2122 dependent on ATP?” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” open=”off”]<\/p>\n

No, unlike firefly-based bioluminescent systems, marine-based bioluminescent systems, including Hikarazine\u2122, do not require ATP.<\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”Are Hikarazine\u2122 substrates patented?” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” open=”off”]<\/p>\n

Yes, Hikarazine\u2122 substrates are patented under EP3615516, US11938199, and JP7366752..<\/p>\n

[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_color=”#FFFFFF” background_color_gradient_direction=”90deg” background_color_gradient_start=”#eeeff3″ background_color_gradient_end=”#aaaaaa” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ header_4_font=”PT Serif|700|||||||” header_4_font_size=”30px” border_color_bottom=”#EEEFF3″ global_colors_info=”{}”]<\/p>\n

Our customers talk about it<\/h4>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][dnxte_testimonial_parent dnxte_testimonial_use_icon=”on” dnxt_testimonial_autoplay_delay=”4000″ dnxt_testimonial_loop=”on” dnxt_testimonial_speed=”1000″ dnxt_testimonial_dots_active_color=”#4D1749″ dnxt_testimonial_pause_on_hover=”on” dnxt_testimonial_rating_color=”#4D1749″ dnxt_testimonial_centered_slides=”on” dnxt_testimonial_image_width=”100px” admin_label=”Antonio Llop” _builder_version=”4.27.5″ _module_preset=”default” header_text_align=”center” global_colors_info=”{}”][dnxte_testimonial_child admin_label_text=”Jasmin Baggenstos, Phalconbio GmbH” dnxte_testimonial_name=”Jasmin BAGGENSTOS ” dnxte_testimonial_position=”Research Scientist and Operations Manager” company_name=”PHALCONBIO” company_link=”https:\/\/www.phalconbio.com\/” company_link_new_window=”on” dnxte_testimonial_description=”<\/p>\n

%22Logotype<\/p>\n

%22Hikarazine Z108 has proven to be a superior substitute for standard luciferine substrate in our work with bioluminescence-based reporter bacteriophages. Its stability is a major advantage: after hydrolysis, the luciferin solution remains viable at -20 \u00b0C for at least two years, while diluted working stocks remain effective for several weeks, unlike standard luciferine substrate, which has a much shorter shelf life. Additionally, Hikarazine Z108 is significantly more cost-effective, with at least a threefold lower cost per measurement. It also produces little to no background luminescence, ensuring more reliable results without requiring a waiting period before use. Lastly, it offers comparable sensitivity for mid-range bioluminescence levels and enhanced sensitivity for both low and high concentrations, enabling the detection of very small numbers of target cells. These advantages make Hikarazine Z108 our preferred substrate for all bioluminescence-based experiments.%22<\/p>\n

” description_bg_color=”RGBA(255,255,255,0)” _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_align=”center” header_text_color=”#4D1749″ position_font=”PT Serif||||||||” position_text_align=”center” company_name_font=”PT Serif|700|||||||” description_font=”Rufina||||||||” description_text_color=”#000000″ description_font_size=”22px” description_quote_border_weight=”4px” description_quote_font=”Rufina||||||||” description_quote_text_color=”#EDE8EC” description_quote_font_size=”13px” width=”%22300%22″ height=”%2292%22″ global_colors_info=”{}”][\/dnxte_testimonial_child][dnxte_testimonial_child admin_label_text=”Zhiyong CHEN” dnxte_testimonial_name=”Zhiyong CHEN” dnxte_testimonial_position=”PhD” company_name=”UNIVERSITY OF ZURICH” company_link=”https:\/\/www.uzh.ch\/en.html” company_link_new_window=”on” dnxte_testimonial_description=”<\/p>\n

%22Logotype<\/p>\n

%22We are using Hikarazine Z108 to screen the urine\/fish pool water containing luciferase-labelled reporter protein for zebrafish model of human kidney disease. Hikarazine shows three times more bioluminescent signals as compared to the standard standard luciferine substrate, which allows to detect lower amount of proteins in the fish pool water.%22<\/p>\n

” _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ position_font=”PT Serif||||||||” company_name_font=”PT Serif|700|||||||” description_font=”Rufina||||||||” description_text_color=”#000000″ description_font_size=”22px” description_quote_border_weight=”4px” description_quote_font=”Rufina||||||||” description_quote_text_color=”#EDE8EC” description_quote_font_size=”13px” width=”%22300%22″ height=”%22104%22″ global_colors_info=”{}”][\/dnxte_testimonial_child][dnxte_testimonial_child admin_label_text=”Zhong YAO” dnxte_testimonial_name=”Zhong YAO” dnxte_testimonial_position=”PhD” company_name=”UNIVERSITY OF TORONTO” company_link=”https:\/\/www.utoronto.ca\/” company_link_new_window=”on” dnxte_testimonial_description=”<\/p>\n

%22Logotype<\/p>\n

%22I am a researcher at the University of Toronto. I developed a novel technique called SIMPL2 which uses split intein coupled with split luciferase to detect protein-protein interactions (PPIs) and their inhibitors. However, several intrinsic issues of conventional luciferase substrate limited the effectiveness of the SIMPL2 assay.
We therefore looked for substitutes and found that Hikarazine compounds outperform other similar substrates in many aspects such as stability, water solubility and brightness. Thus, the utilization of Hikarazine can unleash the full power of SIMPL2 in high throughput studies.%22<\/p>\n

” _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ position_font=”PT Serif||||||||” company_name_font=”PT Serif|700|||||||” company_name_text_align=”center” description_font=”Rufina||||||||” description_text_color=”#000000″ description_font_size=”22px” description_quote_border_weight=”4px” description_quote_font=”Rufina||||||||” description_quote_text_color=”#EDE8EC” description_quote_font_size=”13px” width=”%22300%22″ height=”%22123%22″ global_colors_info=”{}”][\/dnxte_testimonial_child][dnxte_testimonial_child admin_label_text=”David M. MacLean” dnxte_testimonial_name=”David M. MacLean” dnxte_testimonial_position=”PhD – Paul Stark Professor of Pharmacology” company_name=”UNIVERSITY OF ROCHESTER MEDICAL CENTER” company_link=”https:\/\/www.urmc.rochester.edu\/” company_link_new_window=”on” dnxte_testimonial_description=”<\/p>\n

%22UR<\/p>\n

%22Our lab at the University of Rochester is interested in studying the biogenesis and trafficking of membrane proteins. We have developed a split luciferase approach to detect the surface and total abundance of specific membrane proteins in a high-throughput fashion using a plate reader. The ease of use, brightness, and stability of Hikarazine substrates have made a huge difference in the reliability and sensitivity of our studies. In addition, the cost-effectiveness of Hikarazine has enabled us to truly leverage the high-throughput capabilities of plate readers, allowing for more conditions and comparisons than we could otherwise manage.%22<\/p>\n

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%22File:ICFO<\/p>\n

%22We use Hikarazine Z108 as substrate for the enhanced Nano-Lantern (eNL), derived from
Oplophorus gracilirostris. With it, not only have we been able to detect the luminescence
specifically emitted in different tissues of the Caenorhabditis elegans nematode, but also
to couple such light to channelrhodopsins expressed in a nearby cell. We have used
Hikarazine Z108 for imaging from muscles to neurons in sessions that can last up to 2
hours. In the case of functional assays its high stability has allowed us to perform
experiments as long as four hours with no need to refresh the substrate.%22<\/p>\n

” _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ position_font=”PT Serif||||||||” company_name_font=”PT Serif|700|||||||” company_name_text_align=”center” description_font=”Rufina||||||||” description_text_color=”#000000″ description_font_size=”22px” description_quote_border_weight=”4px” description_quote_font=”Rufina||||||||” description_quote_text_color=”#EDE8EC” description_quote_font_size=”13px” width=”%22300%22″ height=”%22123%22″ global_colors_info=”{}”][\/dnxte_testimonial_child][dnxte_testimonial_child admin_label_text=”Antonio Llop” dnxte_testimonial_name=”Antonio Llop” dnxte_testimonial_position=”Researcher Technician ” company_name=”UNIVERSIDAD DE ALICANTE” company_link=”https:\/\/www.ua.es\/en\/” company_link_new_window=”on” dnxte_testimonial_description=”<\/p>\n

%22Universidad<\/p>\n

%22In our lab, we focus on studying the interaction network of a small and unique cyanobacterial protein called PipX.
The recent implementation of a complementation bioluminescence system has allowed us
to analyse the in vivo<\/em> regulation of complex formation in our model organism Synechococcus elongatus<\/em>.
Nevertheless, to enhance the bioluminescence output while maintaining a cost-effective workflow,
we explored alternative pro-substrates for our luciferase.
Hikarazine Z108 meets these criteria and has enabled us to detect even weak interactions.%22<\/p>\n<\/p>\n

” _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ position_font=”PT Serif||||||||” company_name_font=”PT Serif|700|||||||” company_name_text_align=”center” description_font=”Rufina||||||||” description_text_color=”#000000″ description_font_size=”22px” description_quote_border_weight=”4px” description_quote_font=”Rufina||||||||” description_quote_text_color=”#EDE8EC” description_quote_font_size=”13px” width=”%22300%22″ height=”%22123%22″ global_colors_info=”{}”][\/dnxte_testimonial_child][dnxte_testimonial_child admin_label_text=”Andr\u00e9a Brentot” dnxte_testimonial_name=”Andr\u00e9a Brentot” dnxte_testimonial_position=”Research Scientist in Immunology and Immuno-Oncology” company_name=”INSERM CIPHE US 12 MARSEILLE ” company_link=”https:\/\/ciphe.marseille.inserm.fr\/” company_link_new_window=”on” dnxte_testimonial_description=”<\/p>\n

%22Centre<\/p>\n

%22Within the Immunophenomics Center in Marseille, the System Immunomics team conducts, among other things, immuno-oncology projects. In the context of monitoring in vivo tumor growth, our initial experiments showed that compound Z103 is the brightest, compared with the compound we usually use and with Z108 (at equivalent concentrations). Because the signal is strong, we can use lower amounts of the compound, which allows us to reduce the costs associated with bioluminescence experiments, which is very satisfactory.%22<\/p>\n<\/p>\n

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Even
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Cell-Free Systems Applications<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” background_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2022\/01\/Synthelis-MemeUneProteineABesoindExprimerSonPotentiel-Part2.jpg” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” background_layout=”dark” min_height=”50vh” min_height_tablet=”50vh” min_height_phone=”50vh” min_height_last_edited=”on|phone” custom_margin=”0px||||false|false” global_colors_info=”{}”][\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Bioluminescence Pro-substrate Hikarazine\u2122Z108

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<\/div>\n
<\/div>\n \"Hikarazine\n <\/span>\n <\/div>\n
\n \n \n \n <\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>
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<\/div>\n
<\/div>\n \"HIKARAZINE\n <\/span>\n <\/div>\n
\n \n \n \n <\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>
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<\/div>\n
<\/div>\n \"HIKARAZINE\n <\/span>\n <\/div>\n
\n \n \n \n <\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n <\/div>\n
<\/div>\n <\/div>\n \n <\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>Hikarazine\u2122 Z108 is the brightest […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_surecart_dashboard_logo_width":"180px","_surecart_dashboard_show_logo":true,"_surecart_dashboard_navigation_orders":true,"_surecart_dashboard_navigation_invoices":true,"_surecart_dashboard_navigation_subscriptions":true,"_surecart_dashboard_navigation_downloads":true,"_surecart_dashboard_navigation_billing":true,"_surecart_dashboard_navigation_account":true,"footnotes":""},"folder":[49],"class_list":["post-5225","page","type-page","status-publish","hentry"],"yoast_head":"\nBioluminescence Pro-substrate Hikarazine\u2122 Z108 - Synthelis<\/title>\n<meta name=\"description\" content=\"Hikarazine\u2122 Z108: The brightest substrate in the Hikarazine\u2122 range for applications requiring high photon emission.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/synthelis.com\/en\/pro-substrat-bioluminescent-hikarazine-z-108\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bioluminescence Pro-substrate Hikarazine\u2122 Z108 - Synthelis\" \/>\n<meta property=\"og:description\" content=\"Hikarazine\u2122 Z108: The brightest substrate in the Hikarazine\u2122 range for applications requiring high photon emission.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/synthelis.com\/en\/pro-substrat-bioluminescent-hikarazine-z-108\/\" \/>\n<meta property=\"og:site_name\" content=\"Synthelis\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-20T10:47:58+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"9 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/synthelis.com\/en\/pro-substrat-bioluminescent-hikarazine-z-108\/\",\"url\":\"https:\/\/synthelis.com\/en\/pro-substrat-bioluminescent-hikarazine-z-108\/\",\"name\":\"Bioluminescence Pro-substrate Hikarazine\u2122 Z108 - 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