{"id":4528,"date":"2025-03-22T14:00:29","date_gmt":"2025-03-22T14:00:29","guid":{"rendered":"https:\/\/synthelis.com\/?page_id=4528"},"modified":"2025-07-08T12:52:43","modified_gmt":"2025-07-08T12:52:43","slug":"bioproduction-the-future-of-production-is-bio","status":"publish","type":"page","link":"https:\/\/synthelis.com\/en\/bioproduction-the-future-of-production-is-bio\/","title":{"rendered":"Bioproduction \u2013 The future of production is bio."},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px||0px||true|false” global_colors_info=”{}”][et_pb_row column_structure=”1_3,1_3,1_3″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” module_id=”ligne_domainesactivite” _builder_version=”4.27.4″ _module_preset=”default” width=”100%” max_width=”100%” min_height=”50vh” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.27.4″ _module_preset=”default” background_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2022\/03\/Synthelis-Applications-Bioproduction.jpg” global_colors_info=”{}” custom_css_main_element_last_edited=”on|phone” custom_css_main_element_tablet=”width: 100%!important;” custom_css_main_element_phone=”width: 100%!important;”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” background_layout=”dark” min_height=”50vh” min_height_tablet=”50vh” min_height_phone=”50vh” min_height_last_edited=”on|phone” custom_margin=”0px||||false|false” global_colors_info=”{}”][\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” use_background_color_gradient=”on” background_color_gradient_direction=”45deg” background_color_gradient_stops=”#29102e 6%|#4d1749 65%” background_color_gradient_start=”#29102e” background_color_gradient_start_position=”6%” background_color_gradient_end=”#4d1749″ background_color_gradient_end_position=”65%” custom_padding=”78px|65px|78px|65px|true|true” global_colors_info=”{}” custom_css_main_element_last_edited=”on|phone” custom_css_main_element_tablet=”width: 50%!important;” custom_css_main_element_phone=”width: 50%!important;”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”Rufina||||||||” text_text_color=”#FFFFFF” text_font_size=”3em” text_line_height=”1em” header_font=”Rufina||||||||” header_font_size=”55px” header_font_size_tablet=”55px” header_font_size_phone=”40px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

The future<\/span>
of production<\/span>
is bio.<\/span><\/h1>\n

[\/et_pb_text][et_pb_divider show_divider=”off” _builder_version=”4.16″ _module_preset=”default” width=”100%” height=”50px” global_colors_info=”{}”][\/et_pb_divider][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” background_layout=”dark” custom_margin=”0px||||false|false” global_colors_info=”{}”]<\/p>\n

Cell-Free fields of application<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.27.4″ _module_preset=”default” background_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2022\/01\/Synthelis-LesProteinesVeillentSurNous-Part2b.jpg” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” background_layout=”dark” min_height=”25vh” min_height_tablet=”25vh” min_height_phone=”25vh” min_height_last_edited=”on|phone” custom_margin=”0px||||false|false” global_colors_info=”{}”][\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”0px||||false|false” custom_padding=”0px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”25px||25px||true|false” custom_padding=”70px||||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.21.0″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#4D1749″ text_font_size=”1.9em” text_line_height=”1.3em” text_font_size_tablet=”1.7em” text_font_size_phone=”1.6em” text_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

Biomanufacturing consists primarily of synthesising biological products by multiplying cells that incorporate the elements necessary to produce proteins and other specific molecules, thus enabling the mass production of biomolecules of interest.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ header_3_font=”PT Serif|700|||||||” header_3_font_size=”30px” border_color_bottom=”#EEEFF3″ global_colors_info=”{}”]<\/p>\n

Applications<\/h3>\n

[\/et_pb_text][et_pb_divider color=”#D2C6D2″ divider_position=”center” _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||0px||true|false” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#4D1749″ text_font_size=”1.4em” text_line_height=”1.4em” global_colors_info=”{}”]<\/p>\n

The production of biopharmaceuticals is currently a major growth area for biomanufacturing and includes the synthesis of antibiotics, monoclonal antibodies, vaccines, enzymes, modified human proteins, growth factors and viral vectors, for the treatment of various diseases, for which these products have high specificity and efficacy, associated with lesser side effects.<\/strong><\/p>\n

In addition, bioactive natural products (BNP) may be also bioproduced. BNP are compounds that are naturally synthesized by animals, plants or microorganisms, and may act as building blocks, coenzymes, host-defense factors, mediators of gene-expression, cellular signaling or homeostasis. They have been used as pharmaceuticals, nutraceuticals, agrochemicals and cosmetics.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”#4D1749″ text_font_size=”1.4em” text_line_height=”1.4em” global_colors_info=”{}”]<\/p>\n

Among them, we can refer antineoplastics (paclitaxel), anti-tumour agents (mithramycin), immunosuppressants (rapamycin) and antiparasitics (ivermectins). Considering the high global demand for these molecules, their obtention from the corresponding natural sources is not viable due to the limited availability, the complex and expensive extraction and isolation methods, and the low yields. On the other hand, their chemical synthesis in the laboratory may also be problematic due to the high cost of production and complex stereochemistry. By using in vitro cultures of cells to synthesize the biomolecules, production yields are increased and production costs are decreased [1].<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”#EEEFF3″ custom_margin=”||||false|false” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ header_3_font=”PT Serif|700|||||||” header_3_font_size=”30px” border_color_bottom=”#EEEFF3″ global_colors_info=”{}”]<\/p>\n

Technology<\/h3>\n

[\/et_pb_text][et_pb_divider color=”#D2C6D2″ divider_position=”center” _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||0px||true|false” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#4D1749″ text_font_size=”1.4em” text_line_height=”1.4em” global_colors_info=”{}”]<\/p>\n

The therapeutic molecules are manufactured from living organisms such as animals, plants, microorganisms and\/or by biotechnological methods, including recombinant DNA techniques and cell extracts. Non-human mammalian cells are commonly used on an industrial scale, although some human cell lines can be used in vitro.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#4D1749″ text_font_size=”1.4em” text_line_height=”1.4em” global_colors_info=”{}”]<\/p>\n

In addition, cell-free systems based on the use of cell lysates are becoming an important alternative to cell-based systems for the synthesis of various therapeutic biomolecules, as they offer several distinct advantages, such as the possibility of producing proteins that would be difficult or impossible to obtain in living systems, due to their cytotoxicity or due to particular structural characteristics.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”#EDE8EC” custom_margin=”||||false|false” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ header_3_font=”PT Serif|700|||||||” header_3_font_size=”30px” border_color_bottom=”#EEEFF3″ global_colors_info=”{}”]<\/p>\n

Trends and challenges<\/h3>\n

[\/et_pb_text][et_pb_divider color=”#D2C6D2″ divider_position=”center” _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||0px||true|false” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#4D1749″ text_font_size=”1.4em” text_line_height=”1.4em” global_colors_info=”{}”]<\/p>\n

Over the last 30 years, enormous investment and progress has been made in biomanufacturing technologies (Graph 1) and various biopharmaceuticals have been launched on the market. The bioproduction of monoclonal antibodies, for example, has already reached a point of maturity. Furthermore, average yields achieved by commercial-scale manufacturing processes with mammalian systems lie in the range of 70-80%. Downstream processing technologies (including purification) have become more efficient, enabling smaller overall volumes and single-use approaches. It is now easier and faster to establish stable cell lines and cell banks. Nevertheless, the biomanufacturing of certain cell and gene therapies still needs to be improved to reach full maturity.<\/span><\/p>\n

For the near future, the trends in bioproduction include:
. developments in the technology, such as single-use bioprocessing systems and continuous bioprocessing operation modes;
. development of new gene and cell therapies;
. and the implementation or increased use of artificial intelligence and big data analytics.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”#4D1749″ text_font_size=”1.4em” text_line_height=”1.4em” global_colors_info=”{}”]<\/p>\n

The innovations in technology aim to increase automation, as this will maximize bioproduction and minimize capacity constraints. Single-use bioprocessing systems enable to reduce the risk of cross-contamination, increase the flexibility of scaling production and allow a faster setup, enhancing the efficiency and cost-effectiveness of bioproduction. Continuous bioprocessing permits the uninterrupted production, reduces batch-to-batch variability, improves product consistency and lowers production costs [2]. Innovative production methods are needed in order to meet the demands for the production of gene and cell therapies, namely strict quality control and specialized manufacturing techniques [3]. Artificial intelligence can optimize bioprocesses, predict potential failures and analyze vast datasets, leading to more efficient and consistent production. Machine learning models can assist in drug discovery and protein engineering, and data-driven methodologies allow to save time and resources in bioproduction [4].<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_divider color=”#D2C6D2″ divider_position=”center” _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||0px||true|false” global_colors_info=”{}”][\/et_pb_divider][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#4D1749″ text_font_size=”1.4em” text_line_height=”1.4em” global_colors_info=”{}”]<\/p>\n

Graph 1 :<\/strong> Estimated Spending in Biopharmaceutical Research and Development (in USD billion), Gloabl, 2020-2024<\/strong><\/em><\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”http:\/\/synthelis.com\/wp-content\/uploads\/2025\/02\/Bioproduction-Graph1-150-2.png” alt=”Graph 1 : Estimated Spending in Biopharmaceutical Research and Development (in USD billion), Gloabl, 2020-2024″ title_text=”Bioproduction-Graph1-150″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||||false|false” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ header_3_font=”PT Serif|700|||||||” header_3_font_size=”30px” border_color_bottom=”#EEEFF3″ global_colors_info=”{}”]<\/p>\n

Cell-free systems and bioproduction<\/h3>\n

[\/et_pb_text][et_pb_divider color=”#D2C6D2″ divider_position=”center” _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||0px||true|false” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#4D1749″ text_font_size=”1.4em” text_line_height=”1.4em” global_colors_info=”{}”]<\/p>\n

Although bioproduction has been based on the use of cells to synthesize relevant biomolecules, cell-free systems may also be employed in biomanufacturing, and can even exceed the performance of cell-based processes. Cell-free protein synthesis (CFPS) is particularly well-suited to synthesize \u201cdifficult-to-express\u201d proteins such as cytotoxic, misfolded or nonsoluble proteins, which are common among biopharmaceuticals and immunobiological products.<\/span><\/p>\n

\u2028
The open nature of the system allows the addition or removal of substrates and products and the online monitoring of the reaction, for greater control of the process. Furthermore, cell-free technology bypasses cell culturing steps of in vivo methods, accelerating the production and reducing costs. Considering industrial bioproduction, CFPS has the ability to scale up and scale down and enables high throughput production [5,6]. Furthermore, it allows for on-demand production, according to consumers\u2019 needs [7], showing enhanced flexibility versus cell-based biomanufacturing.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.21.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”#4D1749″ text_font_size=”1.4em” text_line_height=”1.4em” global_colors_info=”{}”]<\/p>\n

Portability of cell-free systems and the possibility to use lyophilized cell extracts allow for point-of-care treatments [8,9]. Moreover, the CFPS attractive features open the possibility to shift from the traditional hydrocarbon-dependent processes towards more sustainable biomanufacturing of chemical and biological molecules. It also represents an advantageous alternative in situations where traditional supply chains are compromised by global pandemics, natural disasters or conflict [10]. CFPS has already been used for the bioproduction of biopharmaceuticals, immunobiological and bioactive natural products.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

Written by Lu\u00edsa Silva, PhD and scientific writer.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_color=”#EDE8EC” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ header_3_font=”PT Serif|700|||||||” header_3_font_size=”30px” hover_enabled=”0″ border_color_bottom=”#EEEFF3″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

Publications<\/h3>\n

[\/et_pb_text][et_pb_divider color=”#D2C6D2″ divider_position=”center” _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||0px||true|false” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row make_equal=”on” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

[dnxte_feature_list_parent dnxte_feature_list_item_margin=”||20px||false|false” dnxte_feature_list_item_padding=”||10px||false|false” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||||false|false” custom_padding=”||||false|false” border_color_bottom=”#D2C6D2″ global_colors_info=”{}”][dnxte_feature_list_child dnxte_feature_list_title=”Zhang Y.P., Sun J., Ma Y. 2017. Biomanufacturing: history and perspective. J. Ind. Microbiol. Biotechnol. 44:773-784.” dnxte_feature_list_icon=”h||divi||400″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif|700|||||||” module_text_color=”#4D1749″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1007\/s10295-016-1863-2″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”S\u00fcntar I., \u00c7etinkaya S., Haydaro\u011flu U.S., Habtemariam S. 2021. Bioproduction process of natural products and biopharmaceuticals: biotechnological aspects. Biotechnol. Adv. 50, 107768.” dnxte_feature_list_icon=”h||divi||400″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif|700|||||||” module_text_color=”#4D1749″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1016\/j.biotechadv.2021.107768″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Chiba C.H., Knirsch M.C., Azzoni A.R., Moreira A.R., Stephano M.A. 2021. Cell-free protein synthesis: advances on production process for biopharmaceuticals and immunobiological products. Biotechniques 70, 126-133.” dnxte_feature_list_icon=”h||divi||400″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif|700|||||||” module_text_color=”#4D1749″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.2144\/btn-2020-0155″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Zawada J.F., Burgenson D., Yin G., Hallam T.J., Swartz J.R., Kiss R.D. 2022. Cell-free technologies for biopharmaceutical research and production. Curr. Opin. Biotechnol. 76, 102719.” dnxte_feature_list_icon=”h||divi||400″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif|700|||||||” module_text_color=”#4D1749″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1016\/j.copbio.2022.102719″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][\/dnxte_feature_list_parent]<\/p>\n

[\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”||0px||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ header_3_font=”PT Serif|700|||||||” header_3_font_size=”30px” header_4_font=”PT Serif|700|||||||” header_4_font_size=”22px” border_color_bottom=”#EEEFF3″ global_colors_info=”{}”]<\/p>\n

References<\/h4>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row make_equal=”on” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][dnxte_feature_list_parent dnxte_feature_list_item_margin=”||20px||false|false” dnxte_feature_list_item_padding=”||10px||false|false” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||||false|false” custom_padding=”||||false|false” border_color_bottom=”#D2C6D2″ global_colors_info=”{}”][dnxte_feature_list_child dnxte_feature_list_title=”S\u00fcntar I., \u00c7etinkaya S., Haydaro\u011flu U.S., Habtemariam S. 2021. Bioproduction process of natural products and biopharmaceuticals: biotechnological aspects. Biotechnol. Adv. 50, 107768.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%911%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1016\/j.biotechadv.2021.107768″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Badman C., Cooney C.L., Florence A., Konstantinov K., Krumme M., Mascia S., Nasr M., Trout B.L. 2019. Why we need continuous pharmaceutical manufacturing and how to make it happen. J. Pharm. Sci. 108, 3521-3523.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%912%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1016\/j.xphs.2019.07.016″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Wang B., Bowles-Welch A.C., Yeago C., Roy K. 2022. Process analytical technologies in cell therapy manufacturing: state-of-the-art and future directions. J. Adv. Manuf. Process. 4, e10106.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%913%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1002\/amp2.10106″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Khuat T.T., Bassett R., Otte E., Grevis-James A., Gabrys B. 2024. Applications of machine learning in antibody discovery, process development, manufacturing and formulation: current trends, challenges, and opportunities. Comput. Chem. Eng. 182,108585.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%914%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1016\/j.compchemeng.2024.108585″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Chiba C.H., Knirsch M.C., Azzoni A.R., Moreira A.R., Stephano M.A. 2021. Cell-free protein synthesis: advances on production process for biopharmaceuticals and immunobiological products. Biotechniques 70, 126-133.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%915%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.2144\/btn-2020-0155″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Zawada J.F., Burgenson D., Yin G., Hallam T.J., Swartz J.R., Kiss R.D. 2022. Cell-free technologies for biopharmaceutical research and production. Curr. Opin. Biotechnol. 76, 102719.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%916%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1016\/j.copbio.2022.102719″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Hunt J.P., Wilding K.M., Barnett R.J., Robinson H., Soltani M., Cho J.E., Bundy B.C. 2020. Engineering cell-free protein synthesis for high-yield production and human serum activity assessment of asparaginase: toward on-demand treatment of acute lymphoblastic leukemia. Biotechnol. J. 15, 1900294.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%917%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1002\/biot.201900294″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Pardee K., Slomovic S., Nguyen P.Q., Lee J.W., Donghia N., Burrill D., Ferrante T., McSorley F.R., Furuta Y., Vernet A., Lewandowski M., Boddy C.N., Joshi N.S., Collins J.J. 2016. Portable, on-demand biomolecular manufacturing. Cell 167, 248-259.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%918%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1016\/j.cell.2016.09.013″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Salehi A.S., Smith M.T., Bennett A.M., Williams J.B., Pitt W.G., Bundy B.C. 2016. Cell-free protein synthesis of a cytotoxic cancer therapeutic: onconase production and a just-add-water cell-free system. Biotechnol. J. 11, 274-281.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%919%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1002\/biot.201500237″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Lee S., Kim D. 2024. Cell-free synthesis: expediting biomanufacturing of chemical and biological molecules. Molecules 29, 1878.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%9110%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.3390\/molecules2908187″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][\/dnxte_feature_list_parent][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_color=”#D2C6D2″ background_enable_image=”off” background_size=”initial” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ module_class=”centrer-verticalement” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Rufina||||||||” text_text_color=”#4D1749″ text_font_size=”46px” text_line_height=”40px” custom_margin=”||0px||false|false” text_font_size_tablet=”37px” text_font_size_phone=”35px” text_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

We look
forward to
your questions<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ module_class=”centrer-verticalement” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

[dnxte_button button_text=”Contact us” button_link=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI2NCJ9fQ==@” btn_show_hide=”off” dnxt_hover_2d=”dnxt-hover-float” dnxt_hover_bg_color=”#4D1749″ _builder_version=”4.16.0″ _dynamic_attributes=”button_link” _module_preset=”default” btn_fonts_font=”PT Serif||||||||” btn_fonts_text_color=”#FFFFFF” background_color=”#29102E” use_background_color_gradient=”on” background_color_gradient_type=”linear” background_color_gradient_direction=”-90deg” background_color_gradient_stops=”#29102e 0%|#4d1749 100%” background_color_gradient_start=”#29102e” background_color_gradient_end=”#4d1749″ custom_margin=”||||false|false” custom_padding=”20px|60px|20px|60px|true|true” border_width_all_btn_border=”0px” box_shadow_style=”preset3″ global_colors_info=”{}”][\/dnxte_button]<\/p>\n

[\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px||0px||true|false” global_colors_info=”{}”][et_pb_row column_structure=”1_3,1_3,1_3″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” _builder_version=”4.16″ _module_preset=”default” width=”100%” max_width=”100%” min_height=”70vh” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” background_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2022\/01\/Synthelis-MemeUneProteineABesoindExprimerSonPotentiel-Part1.jpg” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” background_layout=”dark” min_height=”50vh” min_height_tablet=”50vh” min_height_phone=”50vh” min_height_last_edited=”on|phone” custom_margin=”0px||||false|false” global_colors_info=”{}”][\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” use_background_color_gradient=”on” background_color_gradient_direction=”45deg” background_color_gradient_stops=”#29102e 6%|#4d1749 65%” background_color_gradient_start=”#29102e” background_color_gradient_start_position=”6%” background_color_gradient_end=”#4d1749″ background_color_gradient_end_position=”65%” custom_padding=”78px|65px|78px|65px|true|true” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Rufina||||||||” text_text_color=”#FFFFFF” text_font_size=”55px” text_line_height=”1em” text_font_size_tablet=”55px” text_font_size_phone=”40px” text_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

Even
a protein
needs
to express
its potential.<\/p>\n

[\/et_pb_text][et_pb_divider show_divider=”off” _builder_version=”4.16″ _module_preset=”default” width=”100%” height=”50px” global_colors_info=”{}”][\/et_pb_divider][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” background_layout=”dark” custom_margin=”0px||||false|false” global_colors_info=”{}”]<\/p>\n

Cell-Free Systems Applications<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” background_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2022\/01\/Synthelis-LesFuturs-DelInnovationSontBio-Part2.jpg” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” background_layout=”dark” min_height=”50vh” min_height_tablet=”50vh” min_height_phone=”50vh” min_height_last_edited=”on|phone” custom_margin=”0px||||false|false” global_colors_info=”{}”][\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

The futureof productionis bio.Cell-Free fields of applicationBiomanufacturing consists primarily of synthesising biological products by multiplying cells that incorporate the elements necessary to produce proteins and other specific molecules, thus enabling the mass production of biomolecules of interest.ApplicationsThe production of biopharmaceuticals is currently a major growth area for biomanufacturing and includes the synthesis of antibiotics, monoclonal […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_surecart_dashboard_logo_width":"180px","_surecart_dashboard_show_logo":true,"_surecart_dashboard_navigation_orders":true,"_surecart_dashboard_navigation_invoices":true,"_surecart_dashboard_navigation_subscriptions":true,"_surecart_dashboard_navigation_downloads":true,"_surecart_dashboard_navigation_billing":true,"_surecart_dashboard_navigation_account":true,"footnotes":""},"folder":[52],"class_list":["post-4528","page","type-page","status-publish","hentry"],"yoast_head":"\nBioproduction \u2013 The future of production is bio. - Synthelis<\/title>\n<meta name=\"description\" content=\"Learn how Synthelis uses cell-free systems for rapid, flexible and scalable bioproduction of proteins, enzymes, vaccines and more.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/synthelis.com\/en\/bioproduction-the-future-of-production-is-bio\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bioproduction \u2013 The future of production is bio. - Synthelis\" \/>\n<meta property=\"og:description\" content=\"Learn how Synthelis uses cell-free systems for rapid, flexible and scalable bioproduction of proteins, enzymes, vaccines and more.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/synthelis.com\/en\/bioproduction-the-future-of-production-is-bio\/\" \/>\n<meta property=\"og:site_name\" content=\"Synthelis\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-08T12:52:43+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/synthelis.com\/en\/bioproduction-the-future-of-production-is-bio\/\",\"url\":\"https:\/\/synthelis.com\/en\/bioproduction-the-future-of-production-is-bio\/\",\"name\":\"Bioproduction \u2013 The future of production is bio. - Synthelis\",\"isPartOf\":{\"@id\":\"https:\/\/synthelis.com\/en\/#website\"},\"datePublished\":\"2025-03-22T14:00:29+00:00\",\"dateModified\":\"2025-07-08T12:52:43+00:00\",\"description\":\"Learn how Synthelis uses cell-free systems for rapid, flexible and scalable bioproduction of proteins, enzymes, vaccines and more.\",\"breadcrumb\":{\"@id\":\"https:\/\/synthelis.com\/en\/bioproduction-the-future-of-production-is-bio\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/synthelis.com\/en\/bioproduction-the-future-of-production-is-bio\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/synthelis.com\/en\/bioproduction-the-future-of-production-is-bio\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/synthelis.com\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Bioproduction \u2013 The future of production is bio.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/synthelis.com\/en\/#website\",\"url\":\"https:\/\/synthelis.com\/en\/\",\"name\":\"Synthelis\",\"description\":\"Biology at speed\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/synthelis.com\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Bioproduction \u2013 The future of production is bio. - Synthelis","description":"Learn how Synthelis uses cell-free systems for rapid, flexible and scalable bioproduction of proteins, enzymes, vaccines and more.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/synthelis.com\/en\/bioproduction-the-future-of-production-is-bio\/","og_locale":"en_US","og_type":"article","og_title":"Bioproduction \u2013 The future of production is bio. - Synthelis","og_description":"Learn how Synthelis uses cell-free systems for rapid, flexible and scalable bioproduction of proteins, enzymes, vaccines and more.","og_url":"https:\/\/synthelis.com\/en\/bioproduction-the-future-of-production-is-bio\/","og_site_name":"Synthelis","article_modified_time":"2025-07-08T12:52:43+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/synthelis.com\/en\/bioproduction-the-future-of-production-is-bio\/","url":"https:\/\/synthelis.com\/en\/bioproduction-the-future-of-production-is-bio\/","name":"Bioproduction \u2013 The future of production is bio. - Synthelis","isPartOf":{"@id":"https:\/\/synthelis.com\/en\/#website"},"datePublished":"2025-03-22T14:00:29+00:00","dateModified":"2025-07-08T12:52:43+00:00","description":"Learn how Synthelis uses cell-free systems for rapid, flexible and scalable bioproduction of proteins, enzymes, vaccines and more.","breadcrumb":{"@id":"https:\/\/synthelis.com\/en\/bioproduction-the-future-of-production-is-bio\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/synthelis.com\/en\/bioproduction-the-future-of-production-is-bio\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/synthelis.com\/en\/bioproduction-the-future-of-production-is-bio\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/synthelis.com\/en\/"},{"@type":"ListItem","position":2,"name":"Bioproduction \u2013 The future of production is bio."}]},{"@type":"WebSite","@id":"https:\/\/synthelis.com\/en\/#website","url":"https:\/\/synthelis.com\/en\/","name":"Synthelis","description":"Biology at speed","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/synthelis.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/synthelis.com\/en\/wp-json\/wp\/v2\/pages\/4528","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/synthelis.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/synthelis.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/synthelis.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/synthelis.com\/en\/wp-json\/wp\/v2\/comments?post=4528"}],"version-history":[{"count":5,"href":"https:\/\/synthelis.com\/en\/wp-json\/wp\/v2\/pages\/4528\/revisions"}],"predecessor-version":[{"id":6196,"href":"https:\/\/synthelis.com\/en\/wp-json\/wp\/v2\/pages\/4528\/revisions\/6196"}],"wp:attachment":[{"href":"https:\/\/synthelis.com\/en\/wp-json\/wp\/v2\/media?parent=4528"}],"wp:term":[{"taxonomy":"folder","embeddable":true,"href":"https:\/\/synthelis.com\/en\/wp-json\/wp\/v2\/folder?post=4528"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}