{"id":4525,"date":"2025-03-22T14:00:20","date_gmt":"2025-03-22T14:00:20","guid":{"rendered":"https:\/\/synthelis.com\/?page_id=4525"},"modified":"2025-07-08T12:21:58","modified_gmt":"2025-07-08T12:21:58","slug":"point-of-care-bioproduction-the-future-of-healthcare-is-bio","status":"publish","type":"page","link":"https:\/\/synthelis.com\/en\/point-of-care-bioproduction-the-future-of-healthcare-is-bio\/","title":{"rendered":"Point-of-care bioproduction \u2013 The future of healthcare is bio"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px||0px||true|false” global_colors_info=”{}”][et_pb_row column_structure=”1_3,1_3,1_3″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” module_id=”ligne_domainesactivite” _builder_version=”4.16″ _module_preset=”default” width=”100%” max_width=”100%” min_height=”50vh” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” background_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2022\/03\/Synthelis-Applications-Point-of-Care.jpg” global_colors_info=”{}” custom_css_main_element_last_edited=”on|phone” custom_css_main_element_tablet=”width: 100%!important;” custom_css_main_element_phone=”width: 100%!important;”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” background_layout=”dark” min_height=”50vh” min_height_tablet=”50vh” min_height_phone=”50vh” min_height_last_edited=”on|phone” custom_margin=”0px||||false|false” global_colors_info=”{}”][\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” use_background_color_gradient=”on” background_color_gradient_direction=”45deg” background_color_gradient_stops=”#29102e 6%|#4d1749 65%” background_color_gradient_start=”#29102e” background_color_gradient_start_position=”6%” background_color_gradient_end=”#4d1749″ background_color_gradient_end_position=”65%” custom_padding=”78px|65px|78px|65px|true|true” global_colors_info=”{}” custom_css_main_element_last_edited=”on|phone” custom_css_main_element_tablet=”width: 50%!important;” custom_css_main_element_phone=”width: 50%!important;”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Rufina||||||||” text_text_color=”#FFFFFF” text_font_size=”3em” text_line_height=”1em” header_font=”Rufina||||||||” header_font_size=”55px” header_font_size_tablet=”55px” header_font_size_phone=”40px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

The future<\/span>
of healthcare<\/span>
is bio.<\/span><\/h1>\n

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Cell-Free fields of application<\/p>\n

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\u201cPoint of care\u201d (POC) biomanufacturing consists on the development of portable, fully-integrated and closed platforms that incorporate biological materials like yeast cells, bacteria or cell lysates, which are used for the bioproduction of specific products like therapeutic proteins, interferons, recombinant hormones and vaccines at the point of care location.<\/p>\n

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The advantage of this point of care approach to medicine and biomanufacturing is that biologics can be produced in a short time and with lightweight devices, <\/span>allow patients to be treated with biologics in remote locations, on battlefields, in emergency situations, or in underdeveloped areas with poor infrastructure.<\/strong><\/p>\n

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How it works?<\/h2>\n

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The basic components of \u201cpoint-of-care\u201d bioproduction devices are:<\/span>
. a biological expression system<\/strong> designed to express the biotherapeutic product in response to programmable signals,<\/span><\/p>\n

. an integrated microfluidic platform<\/strong> capable of controlling the biomanufacturing process quickly and flexibly, enabling operations to take place remotely.<\/span><\/p>\n

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The biomanufacturing system can be designed to produce more than one biological product simultaneously, provided that they are compatible with one another, and purification methods are integrated into the system. Furthermore, if cell-free extracts are used,<\/span> they can be stored in freeze-dried form and rehydrated<\/strong> with water, prior to being incubated using body heat to activate the extractable components, demonstrating the remarkable portability of such systems.<\/span><\/p>\n

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Shifting to point of care biomanufacturing<\/h2>\n

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Centralized biomanufacturing<\/strong><\/span> in highly specialized facilities has been the dominating model for the production of bioproducts. However, this model imposes limitations<\/strong><\/span> in accessibility and scalability, representing a bottleneck that struggles to keep up with the increasing demand for biotherapies. Recently, COVID-19 pandemic evidenced the need for agile biomanufacturing and distribution frameworks to deliver biologics and biopharmaceuticals worldwide.<\/span><\/p>\n


POC biomanufacturing, enabled by recent developments in technology, can help to overcome these limitations<\/strong><\/span>. One illustrative example is the production of autologous gene and cell therapies, where patient cells have to be transported to the manufacturing facility, processed and returned to the patient, in a process that may take weeks. By shifting to POC bioproduction, the time needed to make the treatment available to the patient and the complexity in logistics are reduced, increasing the accessibility and affordability of treatments [1].<\/span><\/p>\n

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Recently, a microfluidic chip able to produce clinical doses of CAR-T cells for cancer therapy was developed [2]. The ultra-small (with the size of a pack of cards), automated and closed system represents the first use of a microbioreactor for autologous cell therapy, and enables the production of CAR-T cells with the same efficacy of traditional methods at a lower cost. The developed microfluidic chip allowed to diminish the production time in 30-40%, and the small starting cell numbers required, compared to existing larger automated manufacturing platforms, enabled to reduce the amounts of isolation beads, activation reagents and vectors needed per production run, as well as the cell culture volume (2 ml). Besides the reduction in reagent cost, this proposal is also beneficial to pediatric patients who have low or insufficient T-cell numbers to produce therapeutic doses of CAR-T cells.<\/span><\/p>\n

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Challenges<\/h2>\n

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The change towards POC bioproduction is considered critical and an emergence by the European Medicines Agency (EMA) and Food and Drug Administration (FDA)<\/strong><\/span> [3,4], although it is assumed that it will be slow. The existing traditional biomanufacturing has been frequently sufficient but, gradually, the need to replace existing production lines and to proceed to local manufacturing will open opportunities to change to POC production. Another challenge is to assure consistent quality in products biomanufactured by POC systems.<\/span><\/p>\n

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Prefabricated portable cleanrooms and automated processes will allow the standardization of equipments and process, and digital technology will enable to connect the data and quality systems of different locations [5]..<\/span><\/p>\n

Additionally, scaling-down the upstream processing and downstream unit operations performed in traditional bioprocesses, such as purification of the synthesized bioproduct, may arise some difficulties in POC biomanufacturing [6].<\/span><\/p>\n

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Cell-free systems and point of care bioproduction<\/h2>\n

[\/et_pb_text][et_pb_divider color=”#D2C6D2″ divider_position=”center” _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||0px||true|false” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” custom_margin=”25px||25px||true|false” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#4D1749″ text_font_size=”1.4em” text_line_height=”1.4em” global_colors_info=”{}”]<\/p>\n

To address the challenge of downscaling the upstream processing in POC bioproduction, cell-free systems can efficiently replace the traditional cell culture process.<\/strong><\/span> In cell-free synthesis, a lyophilized solution containing cellular components is used in the bioreactor, together with a plasmid containing the sequence for the target protein [6].<\/span><\/p>\n

A successful example of using cell-free systems in POC bioproduction is the Bio-MOD system, that employs a cell-free method for end-to-end continuous manufacturing of biological drug substances [7]. The portable (suitcase-sized) cell-free bioprocessing system integrates machine learning to produce proteins with increased and consistent purity and quality wherein such proteins are prepared on-demand. The system can be scaled-out to enable working with larger volumes.<\/span><\/p>\n

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The machine learning algorithm extracts sufficient data from the process sensors and analytical measurements to ensure the consistency of the process. The algorithm is also able to detect any deviation from the expected, which increases the safety level, compared to the current method of testing a product after it is made.<\/span><\/p>\n

Therapeutics-on-a-chip system was also recently developed and consists on a microfluidic chip containing a cell-free expression system, which was used to produce and purify green fluorescent protein and cecropin B with a high purity and at therapeutically relevant concentrations at a low cost (Figure 1) [8]. The authors used fresh and lyophilized materials for cell-free synthesis of the proteins and applied immunoprecipitation for highly efficient, on-chip protein purification.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_divider color=”#D2C6D2″ divider_position=”center” _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||0px||true|false” global_colors_info=”{}”][\/et_pb_divider][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#4D1749″ text_font_size=”1.4em” text_line_height=”1.4em” global_colors_info=”{}”]<\/p>\n

Figure 1 \u2013 The integrated system for cell-free protein synthesis and purification.<\/strong>\u00a0<\/em><\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”25px||25px||true|false” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”http:\/\/synthelis.com\/wp-content\/uploads\/2025\/02\/Bioproduction-au-pied-du-patient-Figure1-EN_Plan-de-travail-1-copie-2.webp” alt=”Figure 1 \u2013 The integrated system for cell-free protein synthesis and purification. a Micrograph of integrated CFPS + P platform.” title_text=”Bioproduction au pied du patient -Figure1-EN_Plan de travail 1 copie 2″ _builder_version=”4.27.4″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”http:\/\/synthelis.com\/wp-content\/uploads\/2025\/02\/Bioproduction-au-pied-du-patient-Figure1-EN_Plan-de-travail-1-copie-3.webp” alt=”Figure 1 \u2013 The integrated system for cell-free protein synthesis and purification. b Overview of integrated CFPS + P platform setup.” title_text=”Bioproduction au pied du patient -Figure1-EN_Plan de travail 1 copie 3″ _builder_version=”4.27.4″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”#EEEFF3″ global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ header_3_font=”PT Serif|700|||||||” header_3_font_size=”30px” border_color_bottom=”#EEEFF3″ global_colors_info=”{}”]<\/p>\n

Publications<\/h3>\n

[\/et_pb_text][et_pb_divider color=”#D2C6D2″ divider_position=”center” _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||0px||true|false” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row make_equal=”on” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][dnxte_feature_list_parent dnxte_feature_list_item_margin=”||20px||false|false” dnxte_feature_list_item_padding=”||10px||false|false” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||||false|false” custom_padding=”||||false|false” border_color_bottom=”#D2C6D2″ global_colors_info=”{}”][dnxte_feature_list_child dnxte_feature_list_title=”Sin W., Jagannathan N.S., Teo D.B.L., Kairi F., Fong S.Y., Tan J.H.L., Sandikin D., Cheung K., Luah Y.H., Wu X., Raymond J.J., Lim F.L.W.I., Lee Y.H., Seng M.S., Soh S.Y., Chen Q., Ram R.J., Tucker-Kellogg L., Birnbaum M.E. 2024. A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells. Nat. Biomed. Eng. 8, 1571-1591.” dnxte_feature_list_icon=”h||divi||400″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif|700|||||||” module_text_color=”#4D1749″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1038\/s41551-024-01219-1″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Markarian L. 2023. Considering the promises of point-of-care manufacturing. BioPharm Int. 36, 8-11.” dnxte_feature_list_icon=”h||divi||400″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif|700|||||||” module_text_color=”#4D1749″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Thole A., Frey D., Rao G. 2022. Purification challenges for the portable, on-demand point-of-care production of biologics. Curr. Opin. Chem. Eng. 36, 100802.” dnxte_feature_list_icon=”h||divi||400″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif|700|||||||” module_text_color=”#4D1749″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1016\/j.coche.2022.100802″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][\/dnxte_feature_list_parent][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”||0px||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ header_3_font=”PT Serif|700|||||||” header_3_font_size=”30px” header_4_font=”PT Serif|700|||||||” header_4_font_size=”22px” border_color_bottom=”#EEEFF3″ global_colors_info=”{}”]<\/p>\n

References<\/h4>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row make_equal=”on” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][dnxte_feature_list_parent dnxte_feature_list_item_margin=”||20px||false|false” dnxte_feature_list_item_padding=”||10px||false|false” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||||false|false” custom_padding=”||||false|false” border_color_bottom=”#D2C6D2″ global_colors_info=”{}”][dnxte_feature_list_child dnxte_feature_list_title=”Shah M., Krull A., Odonnell L., Lima M.J., Bezerra E. 2023. Promises and challenges of a decentralized CAR T-cell manufacturing model. Front. Transplant. 2, 1238535.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%911%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.3389\/frtra.2023.1238535″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Sin W., Jagannathan N.S., Teo D.B.L., Kairi F., Fong S.Y., Tan J.H.L., Sandikin D., Cheung K., Luah Y.H., Wu X., Raymond J.J., Lim F.L.W.I., Lee Y.H., Seng M.S., Soh S.Y., Chen Q., Ram R.J., Tucker-Kellogg L., Birnbaum M.E. 2024. A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells. Nat. Biomed. Eng. 8, 1571-1591.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%912%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1038\/s41551-024-01219-1″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”European Medicines Agency (EMA) Quality Innovation Group. 2023. Listen and Learn Focus Group Meeting Report.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%913%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Center for Drug Evaluation and Research (CDER). Food and Drug Administration (FDA). 2022. Distributed Manufacturing and Point-of-Care Manufacturing of Drugs, Discussion Paper. FDA.gov.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%914%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Markarian L. 2023. Considering the promises of point-of-care manufacturing. BioPharm Int. 36, 8-11.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%915%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Thole A., Frey D., Rao G. 2022. Purification challenges for the portable, on-demand point-of-care production of biologics. Curr. Opin. Chem. Eng. 36, 100802.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%916%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1016\/j.coche.2022.100802″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Rao G., Kostov Y., Punshon-Smith B., Adiga R. 2023. US Patent 11,685,892 B2. Methods to incorporate machine learning analytics for optimizing protein purity, potency, and quality in an on-demand production system for point-of-care delivery.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%917%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Murphy T.W., Sheng J., Naler L.B., Feng X., Lu C. 2019. On-chip manufacturing of synthetic proteins for point-of-care therapeutics. Microsyst. Nanoeng. 5, 13.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%918%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1038\/s41378-019-0051-8″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][\/dnxte_feature_list_parent][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_color=”#EDE8EC” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ header_2_font=”PT Serif|700|||||||” header_2_font_size=”30px” border_color_bottom=”#EEEFF3″ global_colors_info=”{}”]<\/p>\n

To know more<\/h2>\n

[\/et_pb_text][et_pb_divider color=”#D2C6D2″ divider_position=”center” _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||0px||true|false” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][dnxte_blurb blurb_pre_switch=”on” blurb_pre_heading=”Nature communications” pre_heading_tag=”p” blurb_heading=”Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care” heading_tag=”h3″ dnxt_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2022\/03\/BNatureCommunications.jpg” dnxt_content_max_width=”90%” dnxt_pre_margin=”-30px||10px||false|false” dnxt_pre_padding=”20px|25px||25px|false|true” dnxt_header_padding=”|25px|30px|25px|false|true” dnxt_post_margin=”||||false|false” dnxt_post_padding=”||||false|false” dnxt_body_margin=”|||51px|false|false” dnxt_content_margin=”||||false|false” heading_bg_show_hide=”on” heading_bg=”#f4f4f4″ btn_icon=”5||divi||400″ btn_icon_color=”#FFFFFF” blurb_hover_switch=”on” dnxt_hover_effect=”dnxt-hover-wobble-to-bottom-right” _builder_version=”4.16″ _module_preset=”default” dnxt_pre_header_font=”|700|||||||” dnxt_heading_text_color=”#4D1749″ dnxt_heading_font_size=”30px” dnxt_btn_text_font=”PT Serif||||||||” dnxt_btn_text_text_color=”#FFFFFF” background_color=”RGBA(255,255,255,0)” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/www.nature.com\/articles\/ncomms12211″ link_option_url_new_window=”on” border_width_all_dnxt_button_borders=”0px” box_shadow_style_dnxt_description_boxshadow=”preset3″ box_shadow_style_dnxt_button_boxshadow=”preset3″ global_colors_info=”{}”][\/dnxte_blurb][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][dnxte_blurb blurb_pre_switch=”on” blurb_pre_heading=”Sciences Advances” pre_heading_tag=”p” blurb_heading=”On-demand biomanufacturing of protective conjugate vaccines” heading_tag=”h3″ dnxt_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2022\/03\/ScienceAdvances.jpg” dnxt_content_max_width=”90%” dnxt_pre_margin=”-30px||10px||false|false” dnxt_pre_padding=”20px|25px||25px|false|true” dnxt_header_padding=”|25px|30px|25px|false|true” dnxt_post_margin=”||||false|false” dnxt_post_padding=”||||false|false” dnxt_body_margin=”|||51px|false|false” dnxt_content_margin=”||||false|false” heading_bg_show_hide=”on” heading_bg=”#f4f4f4″ btn_icon=”5||divi||400″ btn_icon_color=”#FFFFFF” blurb_hover_switch=”on” dnxt_hover_effect=”dnxt-hover-wobble-to-bottom-right” _builder_version=”4.16″ _module_preset=”default” dnxt_pre_header_font=”|700|||||||” dnxt_heading_text_color=”#4D1749″ dnxt_heading_font_size=”30px” dnxt_btn_text_font=”PT Serif||||||||” dnxt_btn_text_text_color=”#FFFFFF” background_color=”RGBA(255,255,255,0)” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/www.science.org\/doi\/10.1126\/sciadv.abe9444″ link_option_url_new_window=”on” border_width_all_dnxt_button_borders=”0px” box_shadow_style_dnxt_description_boxshadow=”preset3″ box_shadow_style_dnxt_button_boxshadow=”preset3″ global_colors_info=”{}”][\/dnxte_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_color=”#D2C6D2″ background_enable_image=”off” background_size=”initial” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ module_class=”centrer-verticalement” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Rufina||||||||” text_text_color=”#4D1749″ text_font_size=”46px” text_line_height=”40px” custom_margin=”||0px||false|false” text_font_size_tablet=”37px” text_font_size_phone=”35px” text_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

We look
forward to
your questions<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ module_class=”centrer-verticalement” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][dnxte_button button_text=”Contact us” button_link=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI2NCJ9fQ==@” btn_show_hide=”off” dnxt_hover_2d=”dnxt-hover-float” dnxt_hover_bg_color=”#4D1749″ _builder_version=”4.16.0″ _dynamic_attributes=”button_link” _module_preset=”default” btn_fonts_font=”PT Serif||||||||” btn_fonts_text_color=”#FFFFFF” background_color=”#29102E” use_background_color_gradient=”on” background_color_gradient_type=”linear” background_color_gradient_direction=”-90deg” background_color_gradient_stops=”#29102e 0%|#4d1749 99%” background_color_gradient_start=”#29102e” background_color_gradient_end=”#4d1749″ custom_margin=”||||false|false” custom_padding=”20px|60px|20px|60px|true|true” border_width_all_btn_border=”0px” box_shadow_style=”preset3″ global_colors_info=”{}”][\/dnxte_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px||0px||true|false” global_colors_info=”{}”][et_pb_row column_structure=”1_3,1_3,1_3″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” _builder_version=”4.16″ _module_preset=”default” width=”100%” max_width=”100%” min_height=”70vh” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” background_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2022\/01\/Synthelis-MemeUneProteineABesoindExprimerSonPotentiel-Part1.jpg” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” background_layout=”dark” min_height=”50vh” min_height_tablet=”50vh” min_height_phone=”50vh” min_height_last_edited=”on|phone” custom_margin=”0px||||false|false” global_colors_info=”{}”][\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” use_background_color_gradient=”on” background_color_gradient_direction=”45deg” background_color_gradient_stops=”#29102e 6%|#4d1749 65%” background_color_gradient_start=”#29102e” background_color_gradient_start_position=”6%” background_color_gradient_end=”#4d1749″ background_color_gradient_end_position=”65%” custom_padding=”78px|65px|78px|65px|true|true” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Rufina||||||||” text_text_color=”#FFFFFF” text_font_size=”55px” text_line_height=”1em” text_font_size_tablet=”55px” text_font_size_phone=”40px” text_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

Even
a protein
needs
to express
its potential.<\/p>\n

[\/et_pb_text][et_pb_divider show_divider=”off” _builder_version=”4.16″ _module_preset=”default” width=”100%” height=”50px” global_colors_info=”{}”][\/et_pb_divider][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” background_layout=”dark” custom_margin=”0px||||false|false” global_colors_info=”{}”]<\/p>\n

Cell-Free Systems Applications<\/p>\n

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The futureof healthcareis bio.Cell-Free fields of application\u201cPoint of care\u201d (POC) biomanufacturing consists on the development of portable, fully-integrated and closed platforms that incorporate biological materials like yeast cells, bacteria or cell lysates, which are used for the bioproduction of specific products like therapeutic proteins, interferons, recombinant hormones and vaccines at the point of care location.The […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_surecart_dashboard_logo_width":"180px","_surecart_dashboard_show_logo":true,"_surecart_dashboard_navigation_orders":true,"_surecart_dashboard_navigation_invoices":true,"_surecart_dashboard_navigation_subscriptions":true,"_surecart_dashboard_navigation_downloads":true,"_surecart_dashboard_navigation_billing":true,"_surecart_dashboard_navigation_account":true,"footnotes":""},"folder":[52],"class_list":["post-4525","page","type-page","status-publish","hentry"],"yoast_head":"\nPoint-of-care bioproduction \u2013 The future of healthcare is bio - 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