{"id":4522,"date":"2025-03-22T14:00:46","date_gmt":"2025-03-22T14:00:46","guid":{"rendered":"https:\/\/synthelis.com\/?page_id=4522"},"modified":"2025-07-08T12:51:27","modified_gmt":"2025-07-08T12:51:27","slug":"biomedicines-the-future-of-medicine-is-bio","status":"publish","type":"page","link":"https:\/\/synthelis.com\/en\/biomedicines-the-future-of-medicine-is-bio\/","title":{"rendered":"Biomedicines \u2013 The future of medicine is bio."},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px||0px||true|false” global_colors_info=”{}”][et_pb_row column_structure=”1_3,1_3,1_3″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” module_id=”ligne_domainesactivite” _builder_version=”4.16″ _module_preset=”default” width=”100%” max_width=”100%” min_height=”50vh” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” background_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2022\/03\/Synthelis-Applications-Biomedicaments.jpg” background_position=”top_center” global_colors_info=”{}” custom_css_main_element_last_edited=”on|phone” custom_css_main_element_tablet=”width: 100%!important;” custom_css_main_element_phone=”width: 100%!important;”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” background_layout=”dark” min_height=”50vh” min_height_tablet=”50vh” min_height_phone=”50vh” min_height_last_edited=”on|phone” custom_margin=”0px||||false|false” global_colors_info=”{}”][\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” use_background_color_gradient=”on” background_color_gradient_direction=”45deg” background_color_gradient_stops=”#29102e 6%|#4d1749 65%” background_color_gradient_start=”#29102e” background_color_gradient_start_position=”6%” background_color_gradient_end=”#4d1749″ background_color_gradient_end_position=”65%” custom_padding=”78px|65px|78px|65px|true|true” global_colors_info=”{}” custom_css_main_element_last_edited=”on|phone” custom_css_main_element_tablet=”width: 50%!important;” custom_css_main_element_phone=”width: 50%!important;”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Rufina||||||||” text_text_color=”#FFFFFF” text_font_size=”3em” text_line_height=”1em” header_font=”Rufina||||||||” header_font_size=”55px” header_font_size_tablet=”55px” header_font_size_phone=”40px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

The future<\/span>
of medicine<\/span>
is bio.<\/span><\/h1>\n

[\/et_pb_text][et_pb_divider show_divider=”off” _builder_version=”4.16″ _module_preset=”default” width=”100%” height=”50px” global_colors_info=”{}”][\/et_pb_divider][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” background_layout=”dark” custom_margin=”0px||||false|false” global_colors_info=”{}”]<\/p>\n

Cell-Free fields of application<\/p>\n

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Biomedicines or biological drugs include therapeutic molecules and macromolecules produced by living organisms, as opposed to those produced by chemical synthesis. The active substance is produced or extracted from a biological source.<\/p>\n

\u00a0<\/p>\n

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Biomedicines have existed since ancient times, when organ extracts were administered for therapeutic purposes (blood plasma to treat haemorrhages, spinal cord extract to treat CNS diseases, etc.). The first biomedicine developed on an industrial scale was insulin. Initially extracted from the pancreas of cattle or pigs, it has been produced recombinantly from bacteria since the 1980s. Today, biomedicines include a wide variety of products (see Figure 1).<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ header_2_font=”PT Serif|700|||||||” header_2_font_size=”30px” header_3_font=”PT Serif|700|||||||” header_3_font_size=”30px” border_color_bottom=”#EEEFF3″ global_colors_info=”{}”]<\/p>\n

Diversity of biomedicines<\/h2>\n

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Figure 1:<\/strong>\u00a0<\/em><\/span><\/p>\n

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NUCLEIC ACIDS<\/strong><\/p>\n

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DNA or RNA vaccines<\/strong>
Gene therapies<\/strong><\/p>\n

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PROTEINS<\/strong><\/p>\n

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Subunit vaccines<\/strong>
Enzymes<\/strong>
Growth factors<\/strong>
Protein Hormones<\/strong>
Therapeutic antibodies<\/strong><\/p>\n

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SUGARS<\/strong><\/p>\n

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Heparin<\/strong><\/p>\n

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A market in expansion<\/h2>\n

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Biomedicine is a growing field, shown by the increasing number of publications on the subject, and new developments are being achieved with the integration of state-of-art technologies. In 2023, 59% of all molecules under development in the world were biomedicines, with 26% already in clinical trials. Around 22,000 biotherapy products (with a specific indication) were under development (Figure 2) ([1].<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_divider color=”#D2C6D2″ divider_position=”center” _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||0px||true|false” global_colors_info=”{}”][\/et_pb_divider][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#4D1749″ text_font_size=”1.4em” text_line_height=”1.4em” global_colors_info=”{}”]<\/p>\n

Figure 2 \u2013 Biomedicines (molecules and biotherapies) under development in the world in 2023. Reproduced from [1].<\/strong>\u00a0<\/em><\/span><\/p>\n

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In the world<\/strong>
Molecules en under development \/ 9 931 companies \u2013 37 775 products.<\/strong>
<\/span><\/p>\n

[\/et_pb_text][et_pb_counters _builder_version=”4.27.4″ _module_preset=”default” title_font=”PT Serif|700|||||||” title_text_color=”#4D1749″ title_font_size=”14px” percent_line_height=”2.1em” global_colors_info=”{}”][et_pb_counter percent=”27″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” bar_background_color_default=”#72486e” use_percentages=”on”]R&D[\/et_pb_counter][et_pb_counter percent=”4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” bar_background_color_default=”#72486e” use_percentages=”on”]Phase III[\/et_pb_counter][et_pb_counter percent=”11″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” bar_background_color_default=”#72486e” use_percentages=”on”]Phase II[\/et_pb_counter][et_pb_counter percent=”11″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” bar_background_color_default=”#72486e” use_percentages=”on”]Phase I[\/et_pb_counter][et_pb_counter percent=”47″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” bar_background_color_default=”#72486e” use_percentages=”on”]<\/p>\n

Preclinical<\/p>\n

[\/et_pb_counter][\/et_pb_counters][et_pb_divider color=”#D2C6D2″ divider_position=”center” _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||0px||true|false” global_colors_info=”{}”][\/et_pb_divider][et_pb_counters _builder_version=”4.27.4″ _module_preset=”default” title_font=”PT Serif|700|||||||” title_text_color=”#4D1749″ title_font_size=”14px” percent_line_height=”2.1em” global_colors_info=”{}”][et_pb_counter percent=”59″ bar_background_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” title_text_color=”#29102E” percent_font_size=”30px” global_colors_info=”{}” bar_background_color_default=”#72486e” use_percentages=”on”]<\/p>\n

% of molecules under developmentare biomedicines<\/p>\n

[\/et_pb_counter][\/et_pb_counters][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” custom_margin=”25px||25px||true|false” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#4D1749″ text_font_size=”1.4em” text_line_height=”1.4em” global_colors_info=”{}”]<\/p>\n

In Europe, the top 3 treatment areas using marketed biomedicines were infectious diseases, oncology and metabolic disorders, and the main products were therapeutic proteins, peptides and biopolymers, followed by vaccines (Figure 3) [1].<\/span><\/p>\n

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Figure 3 \u2013 Types of biomedicines marketed in Europe in 2023. Reproduced from [1].<\/strong><\/em><\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.16″ _module_preset=”default” custom_margin=”25px||25px||true|false” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

[dnxte_step_flow dnxte_badge_icon=”\uf471||fa||900″ dnxte_stepflow_title=”511 therapeutic proteins, peptides and biopolymers ” dnxte_stepflow_description=”<\/p>\n

Therapeutic antibodies account for 44% of marketed products in this product familiy.<\/p>\n

” dnxte_use_direction=”off” dnxte_circle_size=”40px” dnxte_circle_bg_color=”#4D1749″ dnxte_circle_color=”#EDE8EC” _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ body_font=”PT Serif||||||||” body_font_size=”16px” background_color=”RGBA(255,255,255,0)” global_colors_info=”{}”][\/dnxte_step_flow]<\/p>\n

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[dnxte_step_flow dnxte_badge_icon=”\uf48e||fa||900″ dnxte_stepflow_title=”158 vaccines ” dnxte_stepflow_description=”<\/p>\n

96% of marketed products are prophylactic vasccines.<\/p>\n

” dnxte_use_direction=”off” dnxte_circle_size=”40px” dnxte_circle_bg_color=”#4D1749″ dnxte_circle_color=”#EDE8EC” _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ body_font=”PT Serif||||||||” body_font_size=”16px” background_color=”RGBA(255,255,255,0)” global_colors_info=”{}”][\/dnxte_step_flow]<\/p>\n

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[dnxte_step_flow dnxte_badge_icon=”\uf46b||fa||900″ dnxte_stepflow_title=”21 advanced therapy medicinal products” dnxte_stepflow_description=”<\/p>\n

Within the ATMP family, 45% of products marketed are CAR-T cell therapies.<\/p>\n

” dnxte_use_direction=”off” dnxte_circle_size=”40px” dnxte_circle_bg_color=”#4D1749″ dnxte_circle_color=”#EDE8EC” _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ body_font=”PT Serif||||||||” body_font_size=”16px” background_color=”RGBA(255,255,255,0)” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][\/dnxte_step_flow]<\/p>\n

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These 690 “unique” biomedicines actually correspond to 4 316 products in a specific indication, with marketing authorisation and marketed in France.<\/span><\/p>\n

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The development of biomedicines<\/strong><\/span> includes a number of stages starting with the identification of therapeutic targets, in which the screening and selection of biomedicinal leads occur.<\/p>\n

These leads are then optimized together with their production system. The selected biomedicines are then subjected to preclinical and clinical evaluation before being approved for marketing.<\/span><\/p>\n

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The stages in the development of biomedicines<\/h3>\n

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[dnxte_timeline timeline_bar_color=”#EDE8EC” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][dnxte_timeline_child timeline_title=”1\/ Target discovery” timeline_content=”<\/p>\n

Program determination.
Target dentification.
Target validation.<\/p>\n

” timeline_use_image=”off” timeline_icon=”\ue0f5||divi||400″ timeline_date=”STRATEGIC RESEARCH” timeline_use_button=”off” timeline_icon_color=”#FFFFFF” timeline_bg_color=”#EDE8EC” icon_bg_color=”#4D1749″ _builder_version=”4.16″ _module_preset=”default” header_text_color=”#4D1749″ content_text_color=”#72486E” identifier_font=”|700|||||||” identifier_text_color=”#29102E” background_color=”RGBA(255,255,255,0)” background_enable_color=”on” box_shadow_style_timeline=”preset3″ box_shadow_style_icon=”preset3″ global_colors_info=”{}”][\/dnxte_timeline_child][dnxte_timeline_child timeline_title=”2\/ Molecule screening” timeline_content=”<\/p>\n

Virtual screening.
Test development.
High throughput screening.
Molecule design.
Selection of high potential molecules.<\/p>\n

” timeline_use_image=”off” timeline_icon=”\uf492||fa||900″ timeline_date=”EXPLORATORY RESEARCH” timeline_use_button=”off” timeline_icon_color=”#FFFFFF” timeline_bg_color=”#EDE8EC” icon_bg_color=”#4D1749″ _builder_version=”4.16″ _module_preset=”default” header_text_color=”#4D1749″ content_text_color=”#72486E” identifier_font=”|700|||||||” identifier_text_color=”#29102E” background_color=”RGBA(255,255,255,0)” background_enable_color=”on” box_shadow_style_timeline=”preset3″ box_shadow_style_icon=”preset3″ global_colors_info=”{}”][\/dnxte_timeline_child][dnxte_timeline_child timeline_title=”3\/ Optimization of the selected molecules” timeline_content=”<\/p>\n

Sequence optimization.
ADME prediction.
Production optimization.<\/p>\n

” timeline_use_image=”off” timeline_icon=”\uf0c3||fa||900″ timeline_use_button=”off” timeline_icon_color=”#FFFFFF” timeline_bg_color=”#EDE8EC” icon_bg_color=”#4D1749″ _builder_version=”4.16″ _module_preset=”default” header_text_color=”#4D1749″ content_text_color=”#72486E” identifier_font=”|700|||||||” identifier_text_color=”#29102E” background_color=”RGBA(255,255,255,0)” background_enable_color=”on” box_shadow_style_timeline=”preset3″ box_shadow_style_icon=”preset3″ global_colors_info=”{}”][\/dnxte_timeline_child][dnxte_timeline_child timeline_title=”4\/ Evaluation of candidates (pre-clinical)” timeline_content=”<\/p>\n

ADME.
Efficacy.
Safety.<\/p>\n

” timeline_use_image=”off” timeline_icon=”N||divi||400″ timeline_date=”CANDIDATE SELECTION” timeline_use_button=”off” timeline_icon_color=”#FFFFFF” timeline_bg_color=”#EDE8EC” icon_bg_color=”#4D1749″ _builder_version=”4.16″ _module_preset=”default” header_text_color=”#4D1749″ content_text_color=”#72486E” identifier_font=”|700|||||||” identifier_text_color=”#29102E” background_color=”RGBA(255,255,255,0)” background_enable_color=”on” box_shadow_style_timeline=”preset3″ box_shadow_style_icon=”preset3″ global_colors_info=”{}”][\/dnxte_timeline_child][dnxte_timeline_child timeline_title=”5\/ Clinical trials” timeline_content=”<\/p>\n

Phase I.
Phase II.
Phase III.<\/p>\n

” timeline_use_image=”off” timeline_icon=”\ue05a||fa||900″ timeline_date=”DEVELOPMENT” timeline_use_button=”off” timeline_icon_color=”#FFFFFF” timeline_bg_color=”#EDE8EC” icon_bg_color=”#4D1749″ _builder_version=”4.16″ _module_preset=”default” header_text_color=”#4D1749″ content_text_color=”#72486E” identifier_font=”|700|||||||” identifier_text_color=”#29102E” background_color=”RGBA(255,255,255,0)” background_enable_color=”on” box_shadow_style_timeline=”preset3″ box_shadow_style_icon=”preset3″ global_colors_info=”{}”][\/dnxte_timeline_child][dnxte_timeline_child timeline_title=”6\/ Review and approval” timeline_use_image=”off” timeline_icon=”\uf007||fa||900″ timeline_use_button=”off” timeline_icon_color=”#FFFFFF” timeline_bg_color=”#EDE8EC” icon_bg_color=”#4D1749″ _builder_version=”4.16″ _module_preset=”default” header_text_color=”#4D1749″ content_text_color=”#72486E” identifier_font=”|700|||||||” identifier_text_color=”#29102E” background_color=”RGBA(255,255,255,0)” background_enable_color=”on” box_shadow_style_timeline=”preset3″ box_shadow_style_icon=”preset3″ global_colors_info=”{}”][\/dnxte_timeline_child][\/dnxte_timeline]<\/p>\n

[\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”introduction” _builder_version=”4.27.4″ _module_preset=”default” background_color=”#EEEFF3″ global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ header_2_font=”PT Serif|700|||||||” header_2_font_size=”30px” header_3_font=”PT Serif|700|||||||” header_3_font_size=”30px” border_color_bottom=”#EEEFF3″ global_colors_info=”{}”]<\/p>\n

Challenges<\/h2>\n

[\/et_pb_text][et_pb_divider color=”#D2C6D2″ divider_position=”center” _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||0px||true|false” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” custom_margin=”25px||25px||true|false” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#4D1749″ text_font_size=”1.4em” text_line_height=”1.4em” global_colors_info=”{}”]<\/p>\n

Biomedicines research is now facing global challenges such as
. the increase of bacterial resistance to antibiotics and the occurrence of superbugs<\/strong><\/span>, which entails the development of alternative and effective antimicrobial treatments and vaccines;
. the need for faster processes<\/strong><\/span> for the discovery of new drugs and for faster clinical trial procedures that will allow a shortening of the required time for the development and validation of new medicines, which can be achieved with the help of generative artificial intelligence and high-throughput experimental validation;<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#4D1749″ text_font_size=”1.4em” text_line_height=”1.4em” global_colors_info=”{}”]<\/p>\n

. and the increased frequency of vaccination<\/strong><\/span>, for example with the periodic flu and COVID-19 re-vaccination, and also the development of mRNA personalized vaccines to treat diseases like cancer, that requires new developments in the mRNA technology to improve precision and personalized therapies. All these challenges demand for effective and powerful analytical instruments and new drug discovery methods.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”introduction” _builder_version=”4.27.4″ _module_preset=”default” background_color=”#EEEFF3″ global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ header_2_font=”PT Serif|700|||||||” header_2_font_size=”30px” header_3_font=”PT Serif|700|||||||” header_3_font_size=”30px” border_color_bottom=”#EEEFF3″ global_colors_info=”{}”]<\/p>\n

Cell-free applications in biomedicines<\/h2>\n

[\/et_pb_text][et_pb_divider color=”#D2C6D2″ divider_position=”center” _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||0px||true|false” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” custom_margin=”25px||25px||true|false” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#4D1749″ text_font_size=”1.4em” text_line_height=”1.4em” global_colors_info=”{}”]<\/p>\n

Cell-free protein synthesis (CFPS) methodology efficiently addresses the challenges in biomedicines production<\/strong><\/span>. This technology is able to produce a large diversity of molecules that can be used as biomedicines, namely antibodies and antibody derivatives, antibody-drug conjugates, cytokines, vaccines and viral proteins [2-4], and cell-free derived products showed to be effective in oncology and infectious diseases applications.<\/span><\/p>\n


For instance, bacteriophages produced in cell-free systems have shown to be potent therapeutics for antibiotic-resistant bacteria [5], and an antibody-drug conjugate comprised by a tubulin inhibitor monomethyl-auristatin-F (MMAF) and a fusion protein (composed of a human Fc domain and a cystine knot miniprotein) was engineered to bind with high affinity to tumor-associated integrin receptors [6]. The fusion protein was expressed by CFPS, during which a non-natural amino acid was introduced into the Fc domain and subsequently used for site-specific conjugation of MMAF through a noncleavable linker.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#4D1749″ text_font_size=”1.4em” text_line_height=”1.4em” global_colors_info=”{}”]<\/p>\n

Furthermore, the cell-free protein production approach allows for high-throughput production of protein libraries and experimental screening in a way that is not feasible in cell-based production, enabling a rapid optimization of the cell-free produced protein [7,8]. Moreover, CFPS platforms are ideal to accelerate the discovery and development of novel biomedicines through the use of artificial intelligence, as cell-free systems allow to experimentally validate, in a rapid way, the thousands of new purpose-built molecules generated by deep learning [9].<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”introduction” _builder_version=”4.16″ _module_preset=”default” background_color=”#D2C6D2″ global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” custom_margin=”25px||25px||true|false” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#000000″ text_font_size=”1.4em” text_line_height=”1.4em” global_colors_info=”{}”]<\/p>\n

\n

SYNTHELIS is proud to participate in a state-sponsored biomedical research program, the \u201cGrand defi\u201d (the Great Challenge) which aims to improve the yields and reduce production costs associated with biomedicine production.<\/span><\/p>\n<\/blockquote>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#4D1749″ text_font_size=”1.4em” text_line_height=”1.4em” global_colors_info=”{}”]<\/p>\n

The \u201ciCFree\u201d program<\/strong><\/span>, carried out in collaboration with the MICALIS, CARMEN and I2BC Institutes, aims to develop cell-free protein production systems. These cell-free systems are optimized by \u201cmachine-learning\u201d methods for the production of therapeutic products that are difficult to obtain in vivo, such as antimicrobial proteins.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”#FFFFFF” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ header_3_font=”PT Serif|700|||||||” header_3_font_size=”30px” hover_enabled=”0″ border_color_bottom=”#EEEFF3″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

Publications<\/h3>\n

[\/et_pb_text][et_pb_divider color=”#D2C6D2″ divider_position=”center” _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||0px||true|false” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row make_equal=”on” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][dnxte_feature_list_parent dnxte_feature_list_item_margin=”||20px||false|false” dnxte_feature_list_item_padding=”||10px||false|false” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||||false|false” custom_padding=”||||false|false” border_color_bottom=”#D2C6D2″ global_colors_info=”{}”][dnxte_feature_list_child dnxte_feature_list_title=”Health Innovation Agency, France Biotech. 2023. Biomedicines and bioproduction. 2023 Overview in France and Europe.” dnxte_feature_list_icon=”h||divi||400″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif|700|||||||” module_text_color=”#4D1749″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Dondapati S.K., Stech M., Zemella A., Kubick S. 2020. Cell-free protein synthesis: a promising option for future drug development. BioDrugs 34, 327-348.” dnxte_feature_list_icon=”h||divi||400″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif|700|||||||” module_text_color=”#4D1749″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1007\/s40259-020-00417-y” link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Chiba C.H., Knirsch M.C., Azzoni A.R., Moreira A.R., Stephano M.A. 2021. Cell-free protein synthesis: advances on production process for biopharmaceuticals and immunobiological products. Biotechniques 70, 126-133.” dnxte_feature_list_icon=”h||divi||400″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif|700|||||||” module_text_color=”#4D1749″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.2144\/btn-2020-0155″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Zawada J.F., Burgenson D., Yin G., Hallam T.J., Swartz J.R., Kiss R.D. 2022. Cell-free technologies for biopharmaceutical research and production. Curr. Opin. Biotechnol. 76, 102719.” dnxte_feature_list_icon=”h||divi||400″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif|700|||||||” module_text_color=”#4D1749″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1016\/j.copbio.2022.102719″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][\/dnxte_feature_list_parent][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”||0px||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ header_3_font=”PT Serif|700|||||||” header_3_font_size=”30px” header_4_font=”PT Serif|700|||||||” header_4_font_size=”22px” border_color_bottom=”#EEEFF3″ global_colors_info=”{}”]<\/p>\n

References<\/h4>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row make_equal=”on” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][dnxte_feature_list_parent dnxte_feature_list_item_margin=”||20px||false|false” dnxte_feature_list_item_padding=”||10px||false|false” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||||false|false” custom_padding=”||||false|false” border_color_bottom=”#D2C6D2″ global_colors_info=”{}”][dnxte_feature_list_child dnxte_feature_list_title=”Health Innovation Agency, France Biotech. 2023. Biomedicines and bioproduction. 2023 Overview in France and Europe.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%911%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Warfel K.F., Williams A., Wong D.A., Sobol S.E., Desai P., Li J., Chang Y., DeLisa M.P., Karim A.S., Jewett M.C. 2022. A low-cost, thermostable, cell-free protein synthesis platform for on-demand production of conjugate vaccines. ACS Synth. Biol. 12, 95-107.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%912%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1021\/acssynbio.2c00392″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Groff D., Carlos N.A., Chen R., Hanson J.A., Liang S., Armstrong S., Li X., Zhou S., Steiner A., Hallam T.J., Yin G. 2022. Development of an E. coli strain for cell-free ADC manufacturing. Biotechnol. Bioeng. 119, 162-175.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%913%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1002\/bit.27961″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Deuker D., Asilonu E., Bracewell D.G., Frank S. 2024. Adeno-associated virus 5 protein particles produced by E. coli cell-free protein synthesis. ACS Synth. Biol. 13, 2710-2717.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%914%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1021\/acssynbio.4c00403″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Emslander Q., Vogele K., Braun P., Stender J., Willy C., Joppich M., Hammerl J.A., Abele M., Meng C., Pichlmair A., Ludwig C., Bugert J.J., Simmel F.C., Westmeyer G.G. 2022. Cell-free production of personalized therapeutic phages targeting multidrug-resistant bacteria. Cell Chem. Biol. 29, 1434-1445.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%915%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1016\/j.chembiol.2022.06.003″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Currier N.V., Ackerman S.E., Kintzing J.R., Chen R., Interrante M.F., Steiner A., Sato A.K., Cochran J.R. 2016. Targeted drug delivery with an integrin-binding knottin\u2013Fc\u2013MMAF conjugate produced by cell-free protein synthesis. Mol. Cancer Ther. 15 1291-1300.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%916%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1158\/1535-7163.MCT-15-0881″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Rasor B.J., V\u00f6geli B., Jewett M.C., Karim A.S. 2022. Cell-free protein synthesis for high-throughput biosynthetic pathway prototyping. Methods Mol. Biol. 2433, 199-215.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%917%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1007\/978-1-0716-1998-8_12.” link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Hunt A.C., V\u00f6geli B., Hassan A.O. Guerrero L., Kightlinger W., Yoesep D.J., Kr\u00fcger A., DeWinter M., Diamond M.S., Karim A.S., Jewett M.C. 2023. A rapid cell-free expression and screening platform for antibody discovery. Nat. Commun. 14, 3897.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%918%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1038\/s41467-023-38965-w” link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][dnxte_feature_list_child dnxte_feature_list_title=”Pandi A., Adam D., Zare A., Trinh V.T., Schaefer S.L., Burt M., Klabunde B., Bobkova E., Kushwaha M., Foroughijabbari Y., Braun P., Spahn C., Preu\u00dfer C., von Strandmann E.P., Bode H.B., von Buttlar H., Bertrams W., Jung A.L., Abendroth F., Schmeck B., Hummer G., V\u00e1zquez O., Erb T.J. 2023. Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides. Nat. Commun. 14, 7197.” dnxte_feature_list_use_number=”on” dnxte_feature_list_number=”%919%93″ dnxte_feature_list_icon_color=”#4D1749″ _builder_version=”4.27.4″ _module_preset=”default” module_font=”PT Serif||||||||” module_text_color=”#000000″ module_font_size=”15px” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/doi.org\/10.1038\/s41467-023-42434-9″ link_option_url_new_window=”on” border_width_bottom=”1px” border_color_bottom=”#D2C6D2″ global_colors_info=”{}” module_text_color__hover_enabled=”on|hover” module_text_color__hover=”#72486E”][\/dnxte_feature_list_child][\/dnxte_feature_list_parent][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_color=”#EDE8EC” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_font=”PT Serif|700|||||||” header_text_color=”#4D1749″ header_5_font=”PT Serif|700|||||||” header_5_font_size=”30px” border_color_bottom=”#EEEFF3″ global_colors_info=”{}”]<\/p>\n

To know more<\/h5>\n

[\/et_pb_text][et_pb_divider color=”#D2C6D2″ divider_position=”center” _builder_version=”4.16″ _module_preset=”default” custom_margin=”0px||0px||true|false” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][dnxte_blurb blurb_pre_switch=”on” blurb_pre_heading=”Biodrugs (pdf)” pre_heading_tag=”p” blurb_heading=”Cell\u2011Free Protein Synthesis: A Promising Option for Future Drug Development” heading_tag=”h6″ dnxt_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2022\/03\/Synthelis-Domaines-Applications-Biomedicaments-1.jpg” dnxt_content_max_width=”90%” dnxt_pre_margin=”-30px||10px||false|false” dnxt_pre_padding=”20px|25px||25px|false|true” dnxt_header_padding=”|25px|30px|25px|false|true” dnxt_post_margin=”||||false|false” dnxt_post_padding=”||||false|false” dnxt_body_margin=”|||51px|false|false” dnxt_content_margin=”||||false|false” heading_bg_show_hide=”on” heading_bg=”#FFFFFF” btn_icon=”5||divi||400″ btn_icon_color=”#FFFFFF” blurb_hover_switch=”on” dnxt_hover_effect=”dnxt-hover-wobble-to-bottom-right” _builder_version=”4.16″ _module_preset=”default” dnxt_pre_header_font=”|700|||||||” dnxt_heading_text_color=”#4D1749″ dnxt_heading_font_size=”30px” dnxt_btn_text_font=”PT Serif||||||||” dnxt_btn_text_text_color=”#FFFFFF” background_color=”RGBA(255,255,255,0)” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7211207\/pdf\/40259_2020_Article_417.pdf” link_option_url_new_window=”on” border_width_all_dnxt_button_borders=”0px” box_shadow_style_dnxt_description_boxshadow=”preset3″ box_shadow_style_dnxt_button_boxshadow=”preset3″ global_colors_info=”{}”][\/dnxte_blurb][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

[dnxte_blurb blurb_pre_switch=”on” blurb_pre_heading=”Research project designed for Sanofi Pasteur (pdf)” pre_heading_tag=”p” blurb_heading=”Solubilisation of a strongly aggregated vaccine antigen” heading_tag=”h4″ dnxt_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2022\/03\/CaseStudy-SanofiPasteur-Vignette2.jpg” dnxt_content_max_width=”90%” dnxt_pre_margin=”-30px||10px||false|false” dnxt_pre_padding=”20px|25px||25px|false|true” dnxt_header_padding=”|25px|30px|25px|false|true” dnxt_post_margin=”||||false|false” dnxt_post_padding=”||||false|false” dnxt_body_margin=”|||51px|false|false” dnxt_content_margin=”||||false|false” heading_bg_show_hide=”on” heading_bg=”#FFFFFF” btn_icon=”5||divi||400″ btn_icon_color=”#FFFFFF” blurb_hover_switch=”on” dnxt_hover_effect=”dnxt-hover-wobble-to-bottom-right” _builder_version=”4.16″ _module_preset=”default” dnxt_pre_header_font=”|700|||||||” dnxt_heading_text_color=”#4D1749″ dnxt_heading_font_size=”30px” dnxt_btn_text_font=”PT Serif||||||||” dnxt_btn_text_text_color=”#FFFFFF” background_color=”RGBA(255,255,255,0)” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”http:\/\/synthelis.com\/wp-content\/uploads\/2022\/03\/CaseStudy-SanofiPasteur.pdf” link_option_url_new_window=”on” border_width_all_dnxt_button_borders=”0px” box_shadow_style_dnxt_description_boxshadow=”preset3″ box_shadow_style_dnxt_button_boxshadow=”preset3″ global_colors_info=”{}”][\/dnxte_blurb]<\/p>\n

[\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

[dnxte_blurb blurb_pre_switch=”on” blurb_pre_heading=”Government – France (pdf)” pre_heading_tag=”p” blurb_heading=”%22New expression systems%22 of the great biomedical challenge” heading_tag=”h6″ dnxt_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2022\/03\/Synthelis-Biomedicaments-GouvernementFrance.jpg” dnxt_content_max_width=”90%” dnxt_pre_margin=”-30px||10px||false|false” dnxt_pre_padding=”20px|25px||25px|false|true” dnxt_header_padding=”|25px|30px|25px|false|true” dnxt_post_margin=”||||false|false” dnxt_post_padding=”||||false|false” dnxt_body_margin=”|||51px|false|false” dnxt_content_margin=”||||false|false” heading_bg_show_hide=”on” heading_bg=”#f4f4f4″ btn_icon=”5||divi||400″ btn_icon_color=”#FFFFFF” blurb_hover_switch=”on” dnxt_hover_effect=”dnxt-hover-wobble-to-bottom-right” _builder_version=”4.16″ _module_preset=”default” dnxt_pre_header_font=”|700|||||||” dnxt_heading_text_color=”#4D1749″ dnxt_heading_font_size=”30px” dnxt_btn_text_font=”PT Serif||||||||” dnxt_btn_text_text_color=”#FFFFFF” background_color=”RGBA(255,255,255,0)” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/www.gouvernement.fr\/sites\/default\/files\/contenu\/piece-jointe\/2021\/06\/20210614_communique_de_presse_biomed.pdf” link_option_url_new_window=”on” border_width_all_dnxt_button_borders=”0px” box_shadow_style_dnxt_description_boxshadow=”preset3″ box_shadow_style_dnxt_button_boxshadow=”preset3″ global_colors_info=”{}”][\/dnxte_blurb]<\/p>\n

[\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

[dnxte_blurb blurb_pre_switch=”on” blurb_pre_heading=”Leem – Biotech Committee (pdf)” pre_heading_tag=”p” blurb_heading=”Biomedicines in France : state of play” heading_tag=”h6″ dnxt_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2022\/03\/Synthelis-Biomedicaments-Leem.jpg” dnxt_content_max_width=”90%” dnxt_pre_margin=”-30px||10px||false|false” dnxt_pre_padding=”20px|25px||25px|false|true” dnxt_header_padding=”|25px|30px|25px|false|true” dnxt_post_margin=”||||false|false” dnxt_post_padding=”||||false|false” dnxt_body_margin=”|||51px|false|false” dnxt_content_margin=”||||false|false” heading_bg_show_hide=”on” heading_bg=”#f4f4f4″ btn_icon=”5||divi||400″ btn_icon_color=”#FFFFFF” blurb_hover_switch=”on” dnxt_hover_effect=”dnxt-hover-wobble-to-bottom-right” _builder_version=”4.16″ _module_preset=”default” dnxt_pre_header_font=”|700|||||||” dnxt_heading_text_color=”#4D1749″ dnxt_heading_font_size=”30px” dnxt_btn_text_font=”PT Serif||||||||” dnxt_btn_text_text_color=”#FFFFFF” background_color=”RGBA(255,255,255,0)” custom_margin=”||||false|false” custom_padding=”||||false|false” link_option_url=”https:\/\/www.leem.org\/sites\/default\/files\/V3%20biom%C3%A9dicament%202013%2023.09.13%20maj%2001.10.13.pdf” link_option_url_new_window=”on” border_width_all_dnxt_button_borders=”0px” box_shadow_style_dnxt_description_boxshadow=”preset3″ global_colors_info=”{}”][\/dnxte_blurb]<\/p>\n

[\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_color=”#D2C6D2″ background_enable_image=”off” background_size=”initial” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ module_class=”centrer-verticalement” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Rufina||||||||” text_text_color=”#4D1749″ text_font_size=”46px” text_line_height=”40px” custom_margin=”||0px||false|false” text_font_size_tablet=”37px” text_font_size_phone=”35px” text_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

We look
forward to
your questions<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ module_class=”centrer-verticalement” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

[dnxte_button button_text=”Contact us” button_link=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI2NCJ9fQ==@” btn_show_hide=”off” dnxt_hover_2d=”dnxt-hover-float” dnxt_hover_bg_color=”#4D1749″ _builder_version=”4.16.0″ _dynamic_attributes=”button_link” _module_preset=”default” btn_fonts_font=”PT Serif||||||||” btn_fonts_text_color=”#FFFFFF” background_color=”#29102E” use_background_color_gradient=”on” background_color_gradient_type=”linear” background_color_gradient_direction=”-90deg” background_color_gradient_stops=”#29102e 0%|#4d1749 100%” background_color_gradient_start=”#29102e” background_color_gradient_end=”#4d1749″ custom_margin=”||||false|false” custom_padding=”20px|60px|20px|60px|true|true” border_width_all_btn_border=”0px” box_shadow_style=”preset3″ global_colors_info=”{}”][\/dnxte_button]<\/p>\n

[\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px||0px||true|false” global_colors_info=”{}”][et_pb_row column_structure=”1_3,1_3,1_3″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” _builder_version=”4.16″ _module_preset=”default” width=”100%” max_width=”100%” min_height=”70vh” custom_padding=”0px||0px||false|false” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” background_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2022\/01\/Synthelis-MemeUneProteineABesoindExprimerSonPotentiel-Part1.jpg” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” background_layout=”dark” min_height=”50vh” min_height_tablet=”50vh” min_height_phone=”50vh” min_height_last_edited=”on|phone” custom_margin=”0px||||false|false” global_colors_info=”{}”][\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” use_background_color_gradient=”on” background_color_gradient_direction=”45deg” background_color_gradient_stops=”#29102e 6%|#4d1749 65%” background_color_gradient_start=”#29102e” background_color_gradient_start_position=”6%” background_color_gradient_end=”#4d1749″ background_color_gradient_end_position=”65%” custom_padding=”78px|65px|78px|65px|true|true” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Rufina||||||||” text_text_color=”#FFFFFF” text_font_size=”55px” text_line_height=”1em” text_font_size_tablet=”55px” text_font_size_phone=”40px” text_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

Even
a protein
needs
to express
its potential.<\/p>\n

[\/et_pb_text][et_pb_divider show_divider=”off” _builder_version=”4.16″ _module_preset=”default” width=”100%” height=”50px” global_colors_info=”{}”][\/et_pb_divider][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” background_layout=”dark” custom_margin=”0px||||false|false” global_colors_info=”{}”]<\/p>\n

Cell-Free Systems Applications<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” background_image=”http:\/\/synthelis.com\/wp-content\/uploads\/2022\/01\/Synthelis-LesFuturs-DelInnovationSontBio-Part2.jpg” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”PT Serif||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” background_layout=”dark” min_height=”50vh” min_height_tablet=”50vh” min_height_phone=”50vh” min_height_last_edited=”on|phone” custom_margin=”0px||||false|false” global_colors_info=”{}”][\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

The futureof medicineis bio.Cell-Free fields of applicationBiomedicines or biological drugs include therapeutic molecules and macromolecules produced by living organisms, as opposed to those produced by chemical synthesis. The active substance is produced or extracted from a biological source. \u00a0Biomedicines have existed since ancient times, when organ extracts were administered for therapeutic purposes (blood plasma to […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_surecart_dashboard_logo_width":"180px","_surecart_dashboard_show_logo":true,"_surecart_dashboard_navigation_orders":true,"_surecart_dashboard_navigation_invoices":true,"_surecart_dashboard_navigation_subscriptions":true,"_surecart_dashboard_navigation_downloads":true,"_surecart_dashboard_navigation_billing":true,"_surecart_dashboard_navigation_account":true,"footnotes":""},"folder":[52],"class_list":["post-4522","page","type-page","status-publish","hentry"],"yoast_head":"\nBiomedicines \u2013 The future of medicine is bio. - Synthelis<\/title>\n<meta name=\"description\" content=\"Discover our cell-free biomedicine platform: fast, flexible production of therapeutics to accelerate medical innovation.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/synthelis.com\/en\/biomedicines-the-future-of-medicine-is-bio\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Biomedicines \u2013 The future of medicine is bio. - 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